资源描述：
《Physicochemical and Interfacial Investigation of Lipid Polymer Particle Assemblies》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、Langmuir2005,21,1305-13131305PhysicochemicalandInterfacialInvestigationofLipid/PolymerParticleAssembliesAnne-LiseTroutier,ThierryDelair,ChristianPichot,andCatherineLadavieÁre*UMR2714CNRS/bioMeÂrieux,SysteÁmesMacromoleÂculairesetPhysiopathologieHumaine,ENSL,46,alleÂed©Italie,69364LyonCedex07
2、,FranceReceivedSeptember20,2004.InFinalForm:November2,2004Amodelstudywasinvestigatedtodevelopcolloidalsupramolecularassembliesconsistingofparticlescoatedwithlipidlayers.Theinteractionsbetweenmonodispersesulfate-chargedpoly(styrene)submicrometerparticlesandzwitterionic/cationiclipidvesiclesc
3、omposedof1,2-dipalmitoyl-sn-glycero-3-phosphocholineand1,2-dipalmitoyl-3-trimethylammoniumpropanewereconsidered.Theinfluenceofrelevantexperimentalparametersonthefinalassociationswasexaminedbyquasi-elasticlightscatteringtopointoutsomenewphenomenaoccurringinthesecolloidalsystems.Themajorroleo
4、felectrostaticinteractionsasdrivingforcestocontroltheorganizationbetweencationiclipidsandoppositelychargedpoly(styrene)particleswasclearlyevident,whereasthisinfluencewaslesspronouncedwhenconsideringthezwitterioniclipids.Thecharacterizationoftheseoriginalcomplexassemblieswascompletedbyathoro
5、ughstudyofthesurfacemodification.Thecombinationofzetapotentialmeasurements,X-rayphotoelectronspectroscopyanalyses,andmicroscopyobservationsprovedthattheenvisionedmodelcanreallycorrespondtopolymerparticlessurroundedbylipids.Introductiontions,wereusedtodeterminemolecularorder,9,10lateraldiffu
6、sion,3,5,7-8,10orphasetransitiontemperature2,6-7ofThedepositionoflipidsinlayersontosphericalcolloidssupportedlipids,aswellaslipid/proteininteractions.4leadstooriginalassemblies(i.e.,aparticlecorecoatedGlassmicrospherescoatedwithphospholipidlayersaswithlipids)thatareofinterestinbiotechnology
7、andasmembranemodelswerealsopreparedtoevaluatethedrug,antigen,orgenedeliverysystems.Indeed,thebindingspecificityofenzymesoncellsurfaces11ortoobtainedcompositestructuresassociatetheadvantagesscrutinizetheparticularlipid/antibodybinding.12,13Aofparticlesand
