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1、JournalofCerebralBloodFlow&Metabolism(2012),112&2012ISCBFMAllrightsreserved0271-678X/12$32.00www.jcbfm.comImagingofperfusion,angiogenesis,andtissueelasticityafterstroke1,32121AbrahamMartı´n,EmilieMace´,RaphaelBoisgard,GabrielMontaldo,BenoitThe´ze´,21MickaelTanterandBe
2、rtrandTavitian12InsermU1023,Universite´ParisSud,CEA,DSV,I2BM,Orsay,France;InstitutLanvegin,ESCPI,Paris,FranceBloodflowinterruptioninacerebralarterycausesbrainischemiaandinducesdramaticchangesofperfusionandmetabolisminthecorrespondingterritory.Weperformedinparallelposi
3、tronemission15tomography(PET)with[O]H2O,singlephotonemissioncomputedtomography(SPECT)with99m99m[Tc]hexamethylpropylene-amino-oxime([Tc]HMPAO)andultrasonicultrafastshearwaveimaging(SWI)during,immediatelyafter,and1,2,4,and7daysaftermiddlecerebralarteryocclusion(MCAO)inr
4、ats.PositronemissiontomographyandSPECTshowedinitialhypoperfusionfollowedbyrecoveryatimmediatereperfusion,hypoperfusionatday1,andhyperperfusionatdays4to7.Hyperperfusioninterestedthewholebrain,includingnonischemicareas.Immunohistochemicalanalysisindicatedactiveangiogene
5、sisatdays2to7,stronglysuggestivethathyperperfusionwassupportedbyanincreaseinmicrovesseldensityinbothbrainhemispheresafterischemia.TheSWIdetectedelasticchangesofcerebraltissueintheischemicareaasearlyasday1afterMCAOappearingasasofteningofcerebraltissuewhoselocalinternal
6、elasticitydecreasedcontinuouslyfromday1to7.Takentogether,theseresultssuggestthathyperperfusionaftercerebralischemiaisduetoformationofneovessels,andindicatethatbrainsofteningisanearlyandcontinuousprocess.TheSWIisapromisingnovelimagingmethodformonitoringtheevolutionofce
7、rebralischemiaovertimeinanimals.JournalofCerebralBloodFlow&Metabolismadvanceonlinepublication,11April2012;doi:10.1038/jcbfm.2012.49Keywords:middlecerebralarteryocclusion;PET;shearwaveimaging;SPECT;stroke;ultrasoundIntroductionbloodflowconditionsthefunctionalrecovery,e
8、lsethelossoffunctionbecomespermanentandcerebralStroke,aleadingcauseofdeathworldwide(Lo´pezsofteningofthetissue,thehallmarkof
