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1、CLINICALTHERAFEUTICSWOL.18,NO.3,1996ComparisonofKetoprofen,Piroxicam,andDiclofenacGelsintheTreatmentofAcuteSoft-TissueInjuryinGeneralPracticeRajniK.Patel,MRCS,MRCGP,’andPeterI?Leswell,CBiol,MIB~o~,~onbehalfoftheGeneralPracticeStudyGroupGarrisonMedicalCentre,Woolwich,London,and2ClinicalRe
2、search,RhBne-PoulencRorer(UK)Ltd.,Eastbourne,EastSussex,UnitedKingdompainonpressure(81%vs78%)andmove-ment(83%vs77%).KetoprofengelalsoTheefficacy,tolerability,andacceptabilitycomparedfavorablywithdiclofenacgel,oftopicalapplicationsofketoprofengelwithalargerproportionofpatientsas-(2.5%w/w)
3、,piroxicamgel(0.5%w/w),sessingagreatimprovementintheinjuryanddiclofenacgel(1%w/w),whenad-(38%vs30%).Patientacceptabilityofke-ministeredthreetimesdailyfor5days,intoprofengelwassignificantlybetterthanthetreatmentofacute(within48hours)piroxicamgel.Morepatientsnotedasig-soft-tissueinjury,wer
4、ecomparedinannificantcoolingeffectwithketoprofengelopen-label,randomized,multicenter,gen-(71%)thanwitheitherpiroxicamgeleralpracticestudy.Of1575patientsre-(49%)ordiclofenacgel(60%).Ketopro-cruited,1048receivedketoprofengel(525fengelalsoshowedexcellenttolerability.usedthegelwithadose-meas
5、uringde-Inconclusion,ketoprofengelmayoffervice),263receivedpiroxicamgel,and264benefitsoverestablishedtherapiesforthereceiveddiclofenacgel.Ketoprofengeltreatmentofacutesoft-tissueinjury.wassignificantlysuperiortopiroxicamgelintermsofglobalassessmentoftreatmentINTRODUCTIONresponse(improvem
6、entin74%vs65%ofpatients)andtheseverityoftheinjuryAcutesoft-tissueinjuryisacommonrea-(38%vs26%greatlyimproved)andinsonforgeneralpracticeconsultation.improvementsinstiffness(71%vs64%),Treatmentusuallyinvolvestopicalappli-restrictionofmobility(34%vs22%),andcationofagentswithcombinedanti-014
7、9-2918/96/$3.50497CLINICALTHERAPEUTICSinflammatoryandanalgesicproperties.PATIENTSANDMETHODSAlthoughthecurrentlyavailabletreat-mentshavebeenshowntobeeffectiveThiswasanopen-label,comparative,par-andwelltolerated,analternativetreat-allel-group,multicenter,generalpracticement
