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1、2.28BioreactorsforTissueEngineering:Design,Applications,andMonitoringJDubois,YMartin,andJAChouinard,UniversitédeSherbrooke,Sherbrooke,QC,CanadaandInstitutuniversitairedegériatriedeSherbrooke,Sherbrooke,QC,CanadaRLecomte,UniversitédeSherbrooke,Sherbro
2、oke,QC,CanadaPVermette,UniversitédeSherbrooke,Sherbrooke,QC,CanadaandInstitutuniversitairedegériatriedeSherbrooke,Sherbrooke,QC,Canada©2011ElsevierB.V.Allrightsreserved.2.28.1Introduction22.28.2EngineeringConceptsinTissueMassGrowth32.28.2.1MassTransf
3、erRequirements32.28.2.2OxygenMassTransfer32.28.2.3WasteMassTransfer72.28.2.4ShearStressinReactors72.28.3ReactorDesignsforTissueEngineering72.28.3.1BagBioreactors/WaveandUndertowBioreactors72.28.3.2PerfusionBioreactors92.28.3.3BiaxialBioreactors112.28
4、.3.4StrainBioreactors122.28.3.5ExamplesofCommerciallyAvailableBioreactorsforTissueEngineering13®2.28.3.5.1RotatingbedbioreactorfromZRPTechnology(GlenMills,USA)132.28.3.5.2Fixed-bedbioreactorfromMedorexandNewBrunswick132.28.3.5.3TheFlexcelltissuetrain
5、culturesystem132.28.4NoninvasiveandNondestructiveImagingTechniquestoMonitorBioreactorTissueCultures132.28.4.1ComputedTomography142.28.4.2MagneticResonanceImaging142.28.4.3PositronEmissionTomography142.28.4.4OtherNoninvasiveModalities152.28.4.5Perspec
6、tives152.28.5Conclusions15Acknowledgment16References16GlossarykLaCoefficientrelatedtothemasstransferresistanceofaComputationalfluiddynamics(CFD)Fieldofresearchspeciesfromonephasetoanother.thatusestransportphenomenonconceptscombinedwithmasstransferMov
7、ementofmass(e.g.,solutesandnumericalmethodsandalgorithmstosolveandanalyzeparticles)fromonepositiontoanother.problemsinvolvingfluidflow.magneticresonanceimaging(MRI)Noninvasivecontinuousstirred-tankreactor(CSTR)Usuallyoperatedmedicalimagingtechniqueus
8、edtovisualizeinternalatsteadystateandassumedtobeperfectlymixed.structuresandsomefunctionsofhumanoranimalCouette–Taylor(rotating-wallperfused)reactorReactorbody.inwhichafluidisconfinedinthegapbetweentwocylinderspositronemissiontomography(PET)Nuclearme
