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1、LETTERSContinuous-flowlithographyforhigh-throughputmicroparticlesynthesisDHANANJAYDENDUKURI,DANIELC.PREGIBON,JESSECOLLINS,T.ALANHATTONANDPATRICKS.DOYLE*DepartmentofChemicalEngineering,MassachusettsInstituteofTechnology,Cambridge,Massachusetts02139,USA*e-mail:pdoyle@mit
2、.eduPublishedonline:9April2006;doi:10.1038/nmat161722reciselyshapedpolymericparticlesandstructuresareisimportantinthedesignofbullet-resistantfabrics,paintsand1widelyusedforapplicationsinphotonicmaterials,consumerproducts.234PMEMS,biomaterialsandself-assembly.CurrentCo
3、mplexparticlesarealsoneededintheemergingfieldof5–1023approachesforparticlesynthesisareeitherbatchprocessesbarcoded-particletechnologies.Existingtechniquestypicallyadd11–1624orflow-throughmicrofluidicschemesthatarebasednewfunctionalgroupsone-by-one.Aone-stepsynthesisishig
4、hlyontwo-phasesystems,limitingthethroughput,shapeanddesired.Challengesalsoexistinaligningparticlesbeforedetection,functionalityoftheparticles.Wereportaone-phasemethodandcustomshapesmayfacilitatethis.thatcombinestheadvantagesofmicroscopeprojectionUsinganewtechnique,wea
5、reabletoovercometheabove7photolithographyandmicrofluidicstocontinuouslyformlimitationstocontinuouslysynthesizeavarietyofdifferentshapesmorphologicallycomplexormultifunctionalparticlesdownusingseveraldifferentoligomersandmakebifunctionalJanustothecolloidallengthscale.Expl
6、oitingtheinhibitionofparticles.Themethodisstraightforwardtoimplementusingafree-radicalpolymerizationnearPDMSsurfaces,weareabletostandardfluorescencemicroscope,andcaneasilybeextendedrepeatedlypatternandflowrowsofparticlesinlessthan0.1s,tocreateparticlesthathavemorethantw
7、odistinctcoded(foraffordingathroughputofnear100particlespersecondusingtheexample,chemically,fluorescently,magnetically)regionsinasimplestofdevicedesigns.Polymerizationwasalsocarriedoutone-stepsynthesis.acrosslaminar,co-flowingstreamstogenerateJanusparticlesInarepresentat
8、iveexperiment,anacrylateoligomercontainingdifferentchemistries,whoserelativeproportionsstream(typicallypoly(ethyleneglycol)di
