Ronco, AKS_a useful term based on evolution in the understanding of AKI, Crit Care 2016

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1、KatzandRoncoCriticalCare(2016)20:23DOI10.1186/s13054-016-1184-xCOMMENTARYOpenAccessAcutekidneystress—ausefultermbasedonevolutionintheunderstandingofacutekidneyinjury1,2*3NevinKatzandClaudioRoncothisstandardrenalfunctiontestinappropriatefortheAbstractearlydiagnosisofAKI.Alt

2、houghtherenalbiomarkerCriticalcarephysicianshavedebatedanappropriateneutrophilgelatinase-associatedlipocalin(NGAL)cantermfortheclinicalphaseprecedingacutekidneybeavaluableclinicaltesttoalertclinicianstosubclinicalinjury(AKI).TherecentdevelopmentofcellcycleAKI,itslackofspec

3、ificityhaslimiteditsuseasasolein-arrestbiomarkersthatsignalthepotentialdicatorofAKI[5].AvarietyofrenalbiomarkershavedevelopmentofAKIispartofanevolutioninthenowbeenidentifiedandhavethepotentialtoenhancemoleculardiagnosisandunderstandingofAKI.Itistheunderstandinganddiagnosis

4、ofAKI,particularlyasproposedthatthepre-injuryphasethatleadstoAKIbiomarkermonitoringiscombinedwithmonitoringcanbedescribedas“acutekidneystress”.Thistermchangesinrenalfunction[6].Theuseofbiomarkersinhasthepotentialtoexpandhorizonsinregardtothecharacterizingcardio-renalsyndro

5、meshasbeende-earlydetectionofsituationsthatwillleadtoAKIandscribed[7].Therecentidentificationofcellcyclearresttheearlyimplementationofcorrectivemeasures.biomarkersthatsignalthepotentialdevelopmentofAKIispartofanevolutioninthemoleculardiagnosisandunderstandingofAKI[8].These

6、biomarkersarereleasedCriticalcarephysicianshavedebatedanappropriatebykidneycellsalongapathwhichmayleadtoAKIdur-termfortheclinicalphaseprecedingacutekidneyinjuryingapre-injuryphase.(AKI).“Renalangina”hasbeenproposed[1];however,itItisproposedthatthepre-injuryphasethatleadsto

7、isrecognizedthatAKIcanresultfromnon-ischemicAKIcanbedescribedas“acutekidneystress”(AKS).mechanisms,andAKIisnotassociatedwithpain.Avar-ThetermAKSseemsappropriateastheunderstandingietyofetiologiesforAKIhavebeenidentified,includingofAKIevolves.ItisdebatableifAKSisaconditionof

8、sepsis,inflammation,toxins,andheartfailure.Examplesveryearlyinjuryoraconditionofincreased