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1、ClinicalInfectiousDiseasesClinicalInfectiousDiseasesAdvanceAccesspublishedDecember16,2015IDSAGUIDELINEClinicalPracticeGuidelinefortheManagementofCandidiasis:2016UpdatebytheInfectiousDiseasesSocietyofAmerica12345678PeterG.Pappas,CarolA.Kauffman,DavidR.Andes,CorneliusJ.Clancy,KierenA.Marr,LuisOstros
2、ky-Zeichner,AnnetteC.Reboli,MindyG.Schuster,9101112JoseA.Vazquez,ThomasJ.Walsh,TheoklisE.Zaoutis,andJackD.Sobel1234UniversityofAlabamaatBirmingham;VeteransAffairsAnnArborHealthcareSystemandUniversityofMichiganMedicalSchool,AnnArbor;UniversityofWisconsin,Madison;Universityof567Pittsburgh,Pennsylvan
3、ia;JohnsHopkinsUniversitySchoolofMedicine,Baltimore,Maryland;UniversityofTexasHealthScienceCenter,Houston;CooperMedicalSchoolofRowanUniversity,891011Camden,NewJersey;UniversityofPennsylvania,Philadelphia;GeorgiaRegentsUniversity,Augusta;WeillCornellMedicalCenterandCornellUniversity,NewYork,NewYork
4、;Children’s12HospitalofPennsylvania,Philadelphia;andHarperUniversityHospitalandWayneStateUniversity,Detroit,MichiganItisimportanttorealizethatguidelinescannotalwaysaccountforindividualvariationamongpatients.Theyarenotintendedtosupplantphysicianjudgmentwithrespecttoparticularpatientsorspecialclinic
5、alsituations.IDSAconsidersadherencetotheseguidelinestobevoluntary,withtheultimatedeterminationregardingtheirapplicationtobemadebythephysicianinthelightDownloadedfromofeachpatient’sindividualcircumstances.Keywords.candidemia;invasivecandidiasis;fungaldiagnostics;azoles;echinocandins.EXECUTIVESUMMAR
6、YendorsedbytheAmericanAcademyofPediatrics(AAP)andhttp://cid.oxfordjournals.org/thePediatricInfectiousDiseasesSociety(PIDS).TheMycosesBackgroundStudyGroup(MSG)hasalsoendorsedtheseguidelines.TheInvasiveinfectionduetoCandidaspeciesislargelyaconditionpanelfollowedaguidelinedevelopmentprocessthathasbee
7、nassociatedwithmedicalprogress,andiswidelyrecognizedasaadoptedbytheInfectiousDiseasesSocietyofAmericamajorcauseofmorbidityandmortalityinthehealthcareenvi-(IDSA),whichincludesasystematicmethodofgradingbothronment.
