Celiac disease confers a 1 6-fold increased risk of asthma A nationwide population-based cohort study

《Celiac disease confers a 1 6-fold increased risk of asthma A nationwide population-based cohort study》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、JALLERGYCLINIMMUNOLLETTERSTOTHEEDITOR1071VOLUME127,NUMBER4fromthisapproach.Toprovidefurthersupportforthisconclusion,disordercharacterizedbyairflowobstructionandinflammation2adouble-blind,placebo-controlledstudyiscurrentlyunderwaytowithaprevalenceof6%to8%inSwedishchildrenandadults.estab

2、lishtheroleofimmunotherapyinthistypeofrhinitis.MostearlierresearchhasindicatedapositiverelationshipbetweenCDandasthmaorairflowobstruction,butrelativeriskestimatesWethankIanJohnstoneforhelpwiththefinalEnglish-languageversionofhavevariedwidelyfrom1.0to7.26,andstudieshavegenerally3thisart

3、icle.sufferedfromsmallnumbers.Throughthepersonalidentitynum-4CarmenRondon,MD,PhDaber,wematchednationwidedataonsmallintestinalbiopsieswithNataliaBlanca-Lopez,MD,PhDbtheSwedishNationalPatientRegister(containingbothinpatientcAnaAranda,BScareandhospitaloutpatientcare)toexaminetheriskof

4、asthmacRocıoHerrera,BSNinpatientswithCD.ThroughlinkageswiththeMedicalBirthReg-cJoseLuisRodriguez-Bada,BSisterandthePrescribedDrugRegister,wealsohadaccesstoinfor-bGabrielaCanto,MD,PhDmationoneducation,cesareansection,bodymassindex,smoking,cCristobalinaMayorga,PhDandasthmamedicationi

5、nasubcohort.aMarıaJoseTorres,MD,PhDaTheexposureofthiscohortstudywasCDaccordingtosmallPalomaCampo,MDaintestinalbiopsy(definedasvillousatrophy,histopathologystageMiguelBlanca,MD,PhDMarsh3;seethisarticle’sTableE1intheOnlineRepositoryatwww.jacionline.org).Weoriginallycollecteddataon351,

6、403bi-abFromAllergyService,CarlosHayaHospital,Malaga,Spain;AllergyService,Infantacopsyreportsrepresenting287,586uniqueindividuals.BiopsiesLeonorHospital,Madrid,Spain;andResearchLaboratory,CarlosHayaHospital-FundacionIMABIS,Malaga,Spain.E-mail:carmenrs61@gmail.com.tookplacefrom1969to2

7、008.Detailsonbiopsydatacollection1,5SupportedbytheFIS-ThematicNetworksandCo-operativeResearchCentres:RIRAAFhavebeenpublishedelsewhere.Inall,thisstudywasbasedon(RD07/0064).28,281individualswithCDand140,295generalpopulationrefer-Disclosureofpotentialconflictofinterest:Theauthorshavedecl

8、aredthatthey