呼吸机治疗的肺保护策略

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1、呼吸机治疗的肺保护策略浙江大学医学院附属儿童医院施丽萍呼吸机相关性肺损伤acuteparenchymallunginjuryandanacuteinflammatoryresponseinthelung.cytokines→alveoliandthesystemiccirculation→multipleorgandysfunctionmortality↑呼吸机相关性肺损伤ventilator-inducedlunginjury容量性损伤Volutrauma（largegasvolumes）压力性

2、损伤Barotrauma（highairwaypressure）不张性损伤Atelectotrauma（alveolarcollapseandre-expansion）生物性损伤Biotrauma（increasedinflammation）肺损伤病理alveolarstructuraldamagepulmonaryedema、inflammation、fibrosissurfactantdysfunctionotherorgandysfunctionexacerbatethedisturbanc

3、eoflungdevelopmentSeminNeonatol.2002Oct;7(5):353-60.ApproachesinthemanagementofacuterespiratoryfailureinchildrenprotectiveventilatoryandpotentialprotectiveventilatorymodeslowertidalvolumeandPEEPpermissivehypercapniahigh-frequencyoscillatoryventilation

4、airwaypressurereleaseventilationpartialliquidventilationimproveoxygenationrecruitmentmaneuverspronepositioningkinetictherapyreduceFiO2andfacilitategasexchangeinhalednitricoxideandsurfactantCurrOpinPediatr.2004Jun;16(3):293-8.Canmechanicalventilationst

5、rategiesreducechroniclungdisease?continuouspositiveairwaypressurepermissivehypercapniapatient-triggeredventilationvolume-targetedventilationproportionalassistventilationhigh-frequencyventilationSeminNeonatol.2003Dec;8(6):441-8小潮气量和呼气末正压lowertidalvolum

6、eandPEEPVentilationwithlowertidalvolumesversustraditionaltidalvolumesinadultsforALIandARDS1202patientslowertidalvolume(≤7ml/kg)lowplateaupressure≤30cmH2Oversustidalvolume10to15ml/kgMortalityatday28long-termmortalitywasuncertainlowandconventionaltidal

7、volumewithplateaupressure≤31cmH2OwasnotsignificantlydifferentCochraneDatabaseSystRev.2004;(2):CD003844Higherversuslowerpositiveend-expiratorypressuresinpatientswiththeacuterespiratorydistresssyndrome549patientsacutelunginjuryandARDSlower-PEEPgroup8.3±

8、3.2cmH2Ohigher-PEEPgroup13.2±3.5cmH2O(P<0.001).tidal-volume6ml/kgend-inspiratoryplateau-pressure≤30cmH2OTheratesofdeath24.9%27.5%(p=0.48)Fromday1today28,breathingwasunassisted14.5±10.4days13.8±10.6days(p=0.5)clinicaloutcomesaresimilarwhetherlo