structure-activity of type I interferons

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1、Biotherapy10:59-86,1997.59~)1997KluwerAcademicPublishers.PrintedintheNetherlands.Structure-activityoftypeIinterferonsGiuseppeC.ViscomiDept.ofBiotechnologyandImmunology,AlfaWassermann,Bologna,ItalyAcceptedinfinalform23July1996Keywords:interferonalpha,interferonbeta,interferonomega,st

2、ructure-activityAbstractTypeIIFNsconsituteafamilyofproteinsexhibitinghighhomologyinprimary,secondary,andtertiarystructures.Theyinteractwiththesamereceptorandtransmitsignalstocellularnucleusthroughasimilarmechanism,elicitingroughlyhomogeneousbiologicalactivity.Nevertheless,themembers

3、ofthatfamily,IFNaspecies,IFNflandIFN~a,duetolocaldifferencesinthestructuresometimeshowdistinctproperties.Fromthereporteddataitresultsthatevenminutechangesordifferencesintheprimarysequencescouldberesponsibleforasignificantvarietyofbiologicalactions,thusinducingtothehypothesisthatType

4、IIFNs,ratherthantobetheresultofaredundantreplicationduringtheevolution,playdefiniterolesinthedefenseoflivingorganismstoforeignagents.Abbreviations:Ab-IFNa-antibodiestoalphainterferon;Ab-IFNfl-antibodiestobetainterferon;Ala-alanine;Arg-arginine;Asp-asparticacid;Bo-bovine;Cys-cysteine

5、;Gin-glutamine;Glu-glutamicacid;Gly-glycine;His-histidine;Hu-human;IFN-interferon;IFNa-alphainterferon;IFNfl-betainterferon;IFN7-gammainterferon;IFN~o-omegainterferon;IFN7--tauinterferon;IFNA-geneofalphainterferon;IFNB-geneofbetainterferon;IFNW-geneofomegainterferon;Ile-isoleucine;J

6、ak-Januskinase;LE-IFNa-leukocytealphainterferon;Leu-leucine;LY-IFNa-lymphoblastoidalphainterferon;Lys-lysine;mAb-monoclonalantibody;Met-methionine;Mu-murine;N-Ab-IFNa-antibodiestoalphainterferonneutralizinginvitroantiviralactivityofalphainterferon;NN-Ab-antibodiestoalphainterferonno

7、nneutralizinginvitroantiviralactivityofalphainterferon;NN-Ab-IFNfl-antibodiestobetainterferonnonneutralizinginvitroantiviralactivityofbetainterferon;Pab-polyclonalantibody;Phe-phenylalanine;polyI:C-polyinosinic:cytidylicacid;Pro-proline;rWNa-recombinantalphainterferon;SDS-PAGE-sodiu

8、mdodecylsulfate-pol