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1、FEBSLetters583(2009)1759–1765journalhomepage:www.FEBSLetters.orgMinireviewAnetworkmedicineapproachtohumandiseaseaaa,b,*AndreasZanzoni,MontserratSoler-López,PatrickAloyaInstituteforResearchinBiomedicine(IRB)andBarcelonaSupercomputingCenter(BSC),c/BaldiriiReixac10-12,08028Barce
2、lona,SpainbInstitucióCatalanadeRecercaiEstudisAvançats(ICREA)Pg.LluísCompanys23,08010Barcelona,SpainarticleinfoabstractArticlehistory:High-throughputinteractiondiscoveryinitiativesareprovidingthousandsofnovelproteininterac-Received2February2009tionswhichareunveilingmanyunexpe
3、ctedlinksbetweenapparentlyunrelatedbiologicalpro-Accepted2March2009cesses.Inparticular,analysesofthefirstdrafthumaninteractomeshighlightastrongassociationAvailableonline6March2009betweenproteinnetworkconnectivityanddisease.Indeed,recentexcitingstudieshaveexploitedtheinformatio
4、ncontainedwithinproteinnetworkstodisclosesomeofthemolecularmechanismsEditedbyMiguelDelaRosaunderlyingcomplexpathologicalprocesses.Thesefindingssuggestthatbothprotein–proteininter-actionsandthenetworksthemselvescouldemergeasanewclassoftargetableentities,boostingtheKeywords:ques
5、tfornoveltherapeuticstrategies.NetworkmedicineÓ2009FederationofEuropeanBiochemicalSocieties.PublishedbyElsevierB.V.Allrightsreserved.Protein–proteininteractionProteinnetworkDrugdiscovery1.Introductionhaverevealedthousandsofunexpectedinteractions,thepooroverlapobservedbetweend
6、ifferentscreensrunonthesameForoveradecade,genome-sequencingprojectshavebeenorganism[8,15]promotedtheconceptionthattheirresultsaredeliveringnearlycompletelistsofthegenesandgeneproductstoodirtytobeapplicable.Ithastakenthecommunityadecadepresentinmanyorganisms,includinghuman[1,2
7、].However,takenofintenseresearchtoretaliatethisnotionandfinally,recentstud-individually,thesecomponentsrevealrelativelylittleabouthowieshaveprovidedageneralframeworktocorrectlyinterpretthecomplexbiologicalsystemsorganizethemanydiscretefunctionsoutcomeofhigh-throughputinteracti
8、ondiscoveryexperimentsneededforsurvival.Virtuallyeveryprocessinacell
