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《Jet Lag- The New England Journal of Medicine (2)》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、ThenewenglandjournalofmedicineclinicalpracticeJetLagRobertL.Sack,M.D.ThisJournalfeaturebeginswithacasevignettehighlightingacommonclinicalproblem.Evidencesupportingvariousstrategiesisthenpresented,followedbyareviewofformalguidelines,whentheyexist.Thearticleendswiththeauthor’
2、sclinicalrecommendations.A55-year-oldphysicianisplanningatripfromLosAngelestoLondontoattendascientificconference.HisprevioustriptoEuropewascomplicatedbysleepinessdur-ingmeetingsanddifficultyfallingasleepandremainingasleepatnight.Hewantstoknowwhathecandotoavoidjetlag.Whatwou
3、ldyouadvise?TheClinicalProblemFromtheDepartmentofPsychiatry,Jetlagisarecognizedsleepdisorder1thatresultsfromcrossingtimezonestoorap-SleepDisordersMedicineProgram,Ore-idlyforthecircadianclocktokeeppace.ThepathophysiologyinvolvesatemporarygonHealthandScienceUniversity,Port-mi
4、salignmentbetweenthecircadianclockandlocaltime.Thecircadianclock,lo-land.AddressreprintrequeststoDr.SackatMailCodeCR139,OregonHealthandcatedinthesuprachiasmaticnucleusofthehypothalamus,isnormallysynchro-ScienceUniversity,3181S.W.SamJack-nizedtothesolarlight–darkcycleandprom
5、otesalertnessduringthedayandsleepsonParkRd.,Portland,OR97201-3098,atnight.Theclockisslowtoreset,sothataftertimezoneshavebeencrossed,theoratsackr@ohsu.edu.endogenoussignalsforsleepandwakefulnessdonotmatchthelocallight–darkNEnglJMed2010;362:440-7.andsocialschedules.Copyright©
6、2010MassachusettsMedicalSociety.Thesymptomsofjetlagconsistprimarilyofinsomniaanddaytimesleepinessbutcanalsoincludedysphoricmood,diminishedphysicalperformance,cognitiveimpairment,andgastrointestinaldisturbances.Jetlagisoftencompoundedbynon-specifictravelfatigue,2whichoccursa
7、saconsequenceofprolongedimmobility,irregularsleeptimesandmealtimes,dehydration,andotherfactorsassociatedwithlong-distanceairtravel,irrespectiveofthecrossingoftimezones.Travelfatiguecanbereversedwithinadayortwowithadequatediet,rest,andsleep,butsymp-tomsofjetlagpersistuntilth
8、ecircadiansystemisrealigned.Althoughjetlagisusuallymedicallybenignandself-limited,
