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1、ARTICLEINPRESSJournalofBiomechanics38(2005)1574–1581www.elsevier.com/locate/jbiomechwww.JBiomech.comCardiovascularstentdesignandvesselstresses:afiniteelementanalysisaba,C.Lally,F.Dolan,P.J.PrendergastaCentreforBioengineering,DepartmentofMechanicalEngineering,TrinityCollege,Dublin2,IrelandbMedt
2、ronicVascular,ParkmoreIndustrialEstate,Galway,IrelandAccepted30July2004AbstractIntravascularstentsofvariousdesignsarecurrentlyinusetorestorepatencyinatheroscleroticcoronaryarteriesandithasbeenfoundthatdifferentstentshavedifferentin-stentrestenosisrates.Ithasbeenhypothesizedthatthelevelofvascul
3、arinjurycausedtoavesselbyastentdeterminesthelevelofrestenosis.Computationalstudiesmaybeusedtoinvestigatethemechanicalbehaviourofstentsandtodeterminethebiomechanicalinteractionbetweenthestentandthearteryinastentingprocedure.Inthispaper,wetestthehypothesisthattwodifferentstentdesignswillprovoked
4、ifferentlevelsofstresswithinanatheroscleroticarteryandhencecausedifferentlevelsofvascularinjury.Thestentsanalysedusingthefinite-elementmethodweretheS7(MedtronicAVE)andtheNIR(BostonScientific)stentdesigns.AnanalysisofthearterialwallstressesinthestentedarteriesindicatesthatthemodularS7stentdesignc
5、auseslowerstresstoanatheroscleroticvesselwithalocalizedstenoticlesioncomparedtotheslottedtubeNIRdesign.Theseresultscorrelatewithobservedclinicalrestenosisrates,whichhavefoundhigherrestenosisratesintheNIRcomparedwiththeS7stentdesign.Therefore,thetestingmethodologyoutlinedhereisproposedasapre-cl
6、inicaltestingtool,whichcouldbeusedtocompareandcontrastexistingstentdesignsandtodevelopnovelstentdesigns.r2004ElsevierLtd.Allrightsreserved.Keywords:Coronarystent;Finite-elementmethod;Restenosis;Vascularinjury;Arterial-wallmechanics1.Introductionetal.,2002;Chuaetal.,2003;Petrinietal.,2004)andni
7、tinolself-expandingstents(Whitcher,1997).However,Manyclinicalstudieshavebeencarriedouttoveryfewanalyseshavebeenperformedontheinterac-investigatetheperformanceofcardiovascularstentstionbetweenthestentandtheartery,eventhoughandithasbeenfo
