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1、ProceedingsSymposiumIEEE/LEOSBeneluxChapter,2007,BrusselsCharacterizationofFemtosecondLaserWrittenWaveguidesforIntegratedBiochemicalSensing11122C.Dongre,R.Dekker,H.J.W.M.Hoekstra,D.Nolli,R.Martinez-Vazquez,R.2221Osellame,P.Laporta,G.Cerullo,andM.Pollnau1In
2、tegratedOpticalMicroSystems,MESA+ResearchInstitute,UniversityofTwente,POBox217,7500AEEnschede,TheNetherlandsE-mail:C.Dongre@ewi.utwente.nl2DipartimentodiFisicaandIstitutodiFotonicaeNanotecnologiedelCNR,PolitecnicodiMilano,PiazzaLeonardodaVinci32,Milano,I-2
3、0133,ItalyFluorescencedetectionisknowntobeoneofthemostsensitiveamongthedifferentopticalsensingtechniques.ThisworkfocusesonexcitationanddetectionoffluorescenceemittedbyDNAstrandslabeledwithfluorescentdyemoleculesthatcanbeexcitedataspecificwavelength.Excitat
4、ionoccursviaopticalchannelwaveguideswrittenwithfemtosecondlaserpulsesappliedcoplanarwithamicrofluidicchannelonaglasschip.Thewaveguidesareopticallycharacterizedinordertofacilitatethedesignofsensingstructureswhichcanbeappliedformonitoringthespatialseparation
5、ofbiochemicalspeciesasaresultofcapillaryelectrophoresis.IntroductionTherecentadvancesinmicrochipfabricationtechnologiesandmicrofluidicshasenabledtheinvestigationofalargenumberofbiochemicalprocessesinminiaturizedlab-on-chipsystems.Thesubstitutionofconventio
6、nalbench-topmeasurementsetupswithon-chipintegrateddetectorswillleadtoafurtherboostforthedevelopmentoflab-on-chipsystems.Inparticular,integratedopticaldetectionhasemergedasanattractivetooltofulfilltherequirementsofsuchanon-chipin-situprobingstrategy[1].Curr
7、entdetectionschemesmostlydependonthehybridintegrationofanexistingmicrofluidicsystemwithexternaldetectionoptics.Thisworkaimsatintegratingbothfunctionalitiesinasinglesubstrate,e.g.aglass.Paralleltotheprogressinglass-basedmicrofluidics,femtosecondlaserwriting
8、hasemergedasaninterestingtechniquetoinscribeopticalwaveguidesinbulkglasssubstrates[2].Thecombinationofthesetwodevelopmentstointegrateadetectionsystemofopticalwaveguideswrittenonaglasslab-on-chipwithafemtoseco
