毕业论文 --比索洛尔和美托洛尔对原发性高血压疗效评价对比研究

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1、HubeiUniversityofChineseMedicine本科毕业论文题目：比索洛尔和美托洛尔对原发性高血压疗效评价对比研究姓名：指导老师：学号：专业：年级：实习单位：目录摘要目的观察研究比索洛尔和美托洛尔治疗各程度高血压的临床效果与安全性评价。方法采用随机、平行、开放的对照方法，观察比索洛尔(n=115)每日2.5～7.5mg或加双氢克尿噻12.5mg,美托洛尔(n=105)每日50～150mg或加双氢克尿噻12.5mg治疗6周和8周的有效率。结果两组治疗第2周开始平均收缩压(SBP)、舒张

2、压(DBP)和心率(HR)较治疗前均明显降低(P<0.01);在整个治疗期间血压和HR持续平稳下降,治疗后2～8周后血压下降值比索洛尔组为10.9/8.7～22.3/16.4mmHg,美托洛尔组为10.9/8.9～16.6/14.7mmHg;HR下降值前组为5.2～9.4次/分,后组为4.7～7.5次/分;服药第8周比索洛尔组降低SBP优于美托洛尔组(P<0.01),其它两组间比较无明显差异(P均>0.05)。比索洛尔和美托洛尔治疗6周降低血压的总体效率分别为84.3%和79.0%(P>0.05);

3、8周加氢氯噻嗪总体效率分别为92.1%和80.7%(P<0.05),比索洛尔加利尿剂可组提高降压疗效7.1%。动态血压监测(ABPM)表明比索洛尔降低夜间SBP优于美托洛尔(P<0.01);比索洛尔T/P比值>50%。结论　比索洛尔是一种有效、高选择性β1受体阻断机制的长效降压药,副作用小,耐受性好。联合应用小剂量中效利尿剂可以提高疗效。关键词：高血压;　比索洛尔;　美托洛尔Abstract:ObjectiveToobservetheclinicaleffectandsafetyevaluation

4、ofthedegreeofhypertensiontreatmentofbisoprololandmetoprolol.Methods：parallelandcontrolmethodofopenobservedbisoprolol(n=115)dailyfrom2.5to7.5mgplushydrochlorothiazide12.5mg,metoprolol(n=105)daily50~150mgorplushydrochlorothiazide12.5mgtreatmentfor6weeksa

5、nd8weeksofefficiency.Results：Comparisonbetweenthevaluedecreased;~group,metoprolol10.9/valueduringthetreatmentresultsofthetwogroupsofthesecondweekaveragesystolicbloodpressure(SBP)anddiastolicbloodpressure(DBP)andheartrate(HR)comparedwithbeforetreatmentw

6、eresignificantlydecreased(P<0.01).InthetreatmentofbloodpressureandHRremainedsteadydecline,thetreatmentafter2~8weeksafterbloodpressuredecreasedbisoprololgroupwas8.7~22.3/16.4mmHg10.9/8.916.6/14.7mmHgHRformergroupwas5.2~9.4times/points,afterthegroupwas4.

7、7~7.5times/points;takingthe8weeksofbisoprololgroupdecreasedSBPisbetterthanmetoprololgroup(P<0.01),andtheothertwogroupshadnosignificantdifference(P>0.05).Theeffectsofbisoprololandmetoprololinthetreatmentof6weekstoreducetheoverallefficiencyofbloodpressur

8、ewere84.3%and79%(P>0.05);8ZhouJiaqinghydrochlorothiazideintheoverallefficiencywere92.1%and80.7%(P<0.05)andbisoprololcombinewithdiureticscangroupenhancetheantihypertensiveefficacyof7.1%.Ambulatorybloodpressuremonitoring(ABPM)showthatSBPi