molecular imprinting technology

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1、TheapplicationanddevelopmentofMolecularimprintingtechnologyAbstract:Molecularimprintingisanewlydevelopedmethodologywhichprovidesmolecularassembliesofdesiredstructuresandpropertiesandisbeingincreasinglyusedforseveralapplicationssuchasinseparationprocesses,microreactors,immunoassaysandantibodymimics

2、,catalysis,artificialenzymes,biosensorrecognitionelementsandbio-andchemo-sensors.Inthispaper,theautherintroductivedtheMolecularimprintingtechnologyanditsapplication.ThetheoryofMolecularimprintingpolymersisalsoreviewedinthispaper.Finally,theautherpresentedtheproblemsandchallengesinmolecularimprintin

3、g.Keywords:Molecularimprinting;Molecularrecognition；Applicationanddevelopment;1.IntroductionMolecularrecognitionisdefinedas‘‘theabilityofonemoleculetoattachtoanothermoleculethathasacomplementaryshape’’[1].Theincentivetodevelopmaterialsthatbindothermoleculesselec7-tivelycomesfromthetremendousmedical

4、andtechnologicalsigni-ficanceofmolecularrecognitioninapplicationsthatincludeaffinit-yseparations,medicaldiagnostics,drugdelivery,chemicalandboilog-icalsensors,andcatalysis.Molecularimprintingcanbeenvisagedastheselectivemanipulat-onoftheshape,sizeandchemicalfunctionalityofapolymermatr-ixbyatemplate

5、molecule.Theimprintingprocessconsistsofthepo-lymerisationoffunctionalmonomersinthepresenceofatemplatespeciesoramoleculecloselyrelatedtothetemplatespecies.Thep-oymerisationisconductedinasolvent(porogen)whichfacilitiesthefomationoftemplate—monomercomplexesbystabilisationofinter-actions.Thesecomplexe

6、sarethenfixedintothisspatialarrangementbytheinclusionofahighproportionofcross-linkingmonomer,whichimpartsrigiditytothepolymernetwork.Removalofthetem-platespeciesaffordsnano-cavites,whicharecomplementaryinsize,shapeandchemicalfunctionalitytothetemplatedspecies.Theseca-vitieshavetheabilitytoselective

7、lyrebindthetemplate.Thegeneralpriniples,areasofapplicationsandlimitationsofimprintedpolymershavebeenextensivelyreviewed[2–6].2.Theapplicationofmolecularimprinting[7]Theconceptofmolecularimprintingbasedonmolecular