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1、THEORGANICCHEMISTRYOFDRUGSYNTHESISVOLUME4DANIELLEDNICERNationalCancerInstituteBethesda,MarylandLESTERA.MITSCHERDepartmentofMedicinalChemistryTheUniversityofKansasLawrence,KansaswithGUNDAI.GEORGDepartmentofMedicinalChemistryTheUniversityofKansasLawrence,KansasAWil
2、ey-IntersciencePublicationJohnWiley&Sons,Inc.NewYork/Chichester/Brisbane/Toronto/SingaporeCopyright©1990byJohnWiley&Sons,Inc.Allrightsreserved.PublishedsimultaneouslyinCanada.ReproductionortranslationofanypartofthisworkbeyondthatpermittedbySection107or108ofthe197
3、6UnitedStatesCopyrightActwithoutthepermissionofthecopyrightownerisunlawful.RequestsforpermissionorfurtherinformationshouldbeaddressedtothePermissionsDepartment,JohnWiley&Sons,Inc.LibraryofCongressCataloginginPublicationData:(Revisedforvolume4)Lednicer,Daniel,1929
4、-Theorganicchemistryofdrugsynthesis."AWiley-Intersciencepublication."IncludesbibliographicalreferencesandIndex.1.Chemistry,Pharmaceutical.2.Drugs.3.Chemistry,Organic-Synthesis.I.Mitscher,LesterA.,jointauthor.II.Title.[DNLM1.Chemistry,Organic.2.Chemistry,Pharmaceu
5、tical.3.Drugs-Chemicalsynthesis.QV744L473o1977]RS403.L38615M976-28387ISBN0-471-85548-0(v.4)PrintedintheUnitedStatesofAmerica10987654321WededicatethisbooktoBeryleandBettywhocontinuetosupportusineveryimaginablewayandtothememoryofKatrinaMitscher-Chapman(1958-1987)wh
6、owaslookingforwardwithhercustomaryenthusiasmtohelpinguspreparethemanuscript.Icannottellhowthetruthmaybe;Isaythetaleas'twassaidtome.SirWalterScott,"TheLayoftheLastMinstrel"PrefaceOveradecadeandahalfhaveflownbysincewestartedonthepreparationofthefirstvolumeinthisser
7、ies.Wedidnotatthattimeenvisageaseriesatallbutsimplyabookwhichfilledwhatwethenperceivedasavacuum.Therewerenotinprintinthemidnineteenseventiesanycontempo-rarymonographsintheEnglishlanguagededicatedtothesynthesisofmedicinalagents.TheresultwastheoriginalOrganicChemis
8、tryofDrugSynthesis.Thereceptionaccordedthatvolumecon-firmedthattherewasindeedaplaceforabookdevotedtothatsubjectmatter.Havinglaidthegroundwork,itseemedworthwhil
