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1、BASICCONCEPTSINBIOCHEMISTRYASTUDENT'SSURVIVALGUIDESecondEditionHIRAMF.GILBERT,Ph.D.ProfessorofBiochemistryBaylorCollegeofMedicineHouston,TexasMcGraw-HillHealthProfessionsDivisionNewYorkSt.LouisSanFranciscoAucklandBogotáCaracasLisbonLondonMadridMexicoCityMilanMontrealNewDelhiSanJuanSingaporeSydney
2、TokyoToronto••••••••••••BASICCONCEPTSINBIOCHEMISTRY,2/ECopyright©2000,1992bytheMcGraw-HillCompanies,Inc.Allrightsreserved.PrintedintheUnitedStatesofAmerica.Exceptasper-mittedundertheUnitedStatesCopyrightActof1976,nopartofthispublicationmaybereproducedordistributedinanyformorbyanymeans,orstoredina
3、databaseorretrievalsystem,withoutthepriorwrittenpermissionofthepublisher.1234567890DOCDOC99ISBN0-07-135657-6ThisbookwassetinTimesRomanbyBetterGraphics,Inc.Theedi-torswereSteveZolloandBarbaraHolton;theproductionsupervisorwasRichardRuzycka;theindexwaspreparedbyJerryRalya.R.R.DonnelleyandSonswasthep
4、rinterandbinder.Thisbookisprintedonacid-freepaper.Cataloging-in-PublicationDataisonfileforthisbookattheLibraryofCongress.•PROLOGUE•BasicConceptsinBiochemistry:AStudent’sSurvivalGuideisnotacon-ventionalbook:Itisnotareviewbookoratextbookoraproblembook.Itisabookthatoffershelpintwodifferentways—helpi
5、nunderstandingtheconceptsofbiochemistryandhelpinorganizingyourattackonthesubjectandminimizingthesubject’sattackonyou.Thisbookpresentswhatareoftenviewedasthemoredifficultcon-ceptsinanintroductorybiochemistrycourseanddescribestheminenoughdetailandinsimpleenoughlanguagetomakethemunderstand-able.Wesu
6、rveyedfirst-andsecond-yearmedicalstudentsatanationalstudentmeetingaskingthemtolist,inorder,thepartsofbiochemistrytheyfoundmostdifficulttounderstand.Thewinner(orloser),byfar,wasintegrationofmetabolism.Metaboliccontrol,pH,andenzymekineticsrancloselybehind,withnotablementiongiventomolecularbiologyan
7、dproteins.Biochemistrytextsandbiochemistryprofessorsareburdenedwiththetaskofpresentingfacts,andtheenormityofthistaskcangetinthewayofexplainingconcepts.SinceIdon’tfeelburdenedbythatnecessity,I’veonlyoutlinedmostofthefac
