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1、BASICCONCEPTSINBIOCHEMISTRYASTUDENT'SSURVIVALGUIDESecondEditionHIRAMF.GILBERT,Ph.D.ProfessorofBiochemistryBaylorCollegeofMedicineHouston,TexasMcGraw-HillHealthProfessionsDivisionNewYorkSt.LouisSanFranciscoAucklandBogotáCaracasLisbonLondonMadridMexicoCityMilanMontrealNewDelhiSanJuanSingapore
2、SydneyTokyoToronto••••••••••••BASICCONCEPTSINBIOCHEMISTRY,2/ECopyright©2000,1992bytheMcGraw-HillCompanies,Inc.Allrightsreserved.PrintedintheUnitedStatesofAmerica.Exceptasper-mittedundertheUnitedStatesCopyrightActof1976,nopartofthispublicationmaybereproducedordistributedinanyformorbyanymeans
3、,orstoredinadatabaseorretrievalsystem,withoutthepriorwrittenpermissionofthepublisher.1234567890DOCDOC99ISBN0-07-135657-6ThisbookwassetinTimesRomanbyBetterGraphics,Inc.Theedi-torswereSteveZolloandBarbaraHolton;theproductionsupervisorwasRichardRuzycka;theindexwaspreparedbyJerryRalya.R.R.Donne
4、lleyandSonswastheprinterandbinder.Thisbookisprintedonacid-freepaper.Cataloging-in-PublicationDataisonfileforthisbookattheLibraryofCongress.•PROLOGUE•BasicConceptsinBiochemistry:AStudent’sSurvivalGuideisnotacon-ventionalbook:Itisnotareviewbookoratextbookoraproblembook.Itisabookthatoffershelp
5、intwodifferentways—helpinunderstandingtheconceptsofbiochemistryandhelpinorganizingyourattackonthesubjectandminimizingthesubject’sattackonyou.Thisbookpresentswhatareoftenviewedasthemoredifficultcon-ceptsinanintroductorybiochemistrycourseanddescribestheminenoughdetailandinsimpleenoughlanguage
6、tomakethemunderstand-able.Wesurveyedfirst-andsecond-yearmedicalstudentsatanationalstudentmeetingaskingthemtolist,inorder,thepartsofbiochemistrytheyfoundmostdifficulttounderstand.Thewinner(orloser),byfar,wasintegrationofmetabolism.Metaboliccontrol,pH,andenzymekineticsrancloselybehind,withnot
7、ablementiongiventomolecularbiologyandproteins.Biochemistrytextsandbiochemistryprofessorsareburdenedwiththetaskofpresentingfacts,andtheenormityofthistaskcangetinthewayofexplainingconcepts.SinceIdon’tfeelburdenedbythatnecessity,I’veonlyoutlinedmostofthefac
