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1、BiosensorsandBioelectronics22(2006)558562AflexibleandwearableglucosesensorbasedonfunctionalpolymerswithSoft-MEMStechniquesHiroyukiKudoa,TakanoriSawadaa,ElitoKazawab,HiromichiYoshidab,YasuhikoIwasakic,KohjiMitsubayashia,∗aDepartmentofBiomedicalDevicesandInstrumentation,Instituteof
2、BiomaterialsandBioengineering,TokyoMedicalandDentalUniversity,2-3-10Kanda-Surugadai,Chiyoda-ku,Tokyo101-0062,JapanbTokyoMetropolitanIndustrialTechnologyResearchInstitute,JapancDepartmentofOrganicMaterials,InstituteofBiomaterialsandBioengineering,TokyoMedicalandDentalUniversity,J
3、apanReceived15February2006;receivedinrevisedform26April2006;accepted2May2006Availableonline13June2006AbstractAnovelbiosensorforglucosemeasurementusingfunctionalpolymerswasfabricatedandtested.Thebiosensorutilizesthephysicalandchemicalfunctionsofhydrophobicpolydimethylsiloxane(PDM
4、S)andhydrophilic2-methacryloyloxyethylphosphorylcholine(MPC)copolymerizedwithdodecylmethacrylate(DMA).Theglucosesensorwasconstructedbyimmobilizingglucoseoxidase(GOD)ontoaflexiblehydrogenperoxideelectrode(PtworkingelectrodeandAg/AgClcounter/referenceelectrode).Theelectrodeswerefab
5、ricatedusingmicroelectromechanicalsystems(MEMS)techniquesontothosefunctionalpolymers.Thesensorshowednovelfunctionsofflexibilityanditwasstretchablesothatthesensorcouldnormallyworkwhenitwasreleasedafterexpandingto120%longerthanthatofnormallength.Also,basiccharacteristicsofthesensor
6、wereevaluated.Theoutputcurrentofthehydrogenperoxideelectrodewaslinearlyrelatedtothehydrogenperoxideconcentrationinarangeof0.202.50mmol/l,withacorrelationcoefficientof0.998.GODwasthenimmobilizedontothesurfaceofthesensorusingMPCpolymer.Inthiscase,thecurrentoutputoftheglucosesensorr
7、elatedtotheglucoseleveloverarangeof0.062.00mmol/l,withacorrelationcoefficientof0.997.Thecalibrationrangeincludesthereportedconcentrationoftearglucoseinnormalhumansubject(0.14mmol/l).©2006ElsevierB.V.Allrightsreserved.Keywords:Biosensor;Phospholipidpolymer;MPC;PDMS;Flexible;Glucos
8、esensor1.Introduction2003).Althoughmanykindsofb
