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1、ElectrochemistryCommunications47(2014)58–62ContentslistsavailableatScienceDirectElectrochemistryCommunicationsjournalhomepage:www.elsevier.com/locate/elecomShortcommunicationMicroneedle-basedself-poweredglucosesensoraa,baaaGabrielaValdés-Ramírez,Ya-ChiehLi,Jayo
2、ungKim,WenzhaoJia,AmayJ.Bandodkar,ac,dbdeRogelioNuñez-Flores,PhilipR.Miller,Shu-YiiWu,RogerNarayan,JoshuaR.Windmiller,ca,⁎RonenPolsky,JosephWangaDepartmentofNanoEngineering,UniversityofCalifornia,SanDiego,LaJolla,CA92093-0448,USAbDepartmentofChemicalEngineering
3、,FengChiaUniversity,Taichung40724,TaiwancSandiaNationalLaboratories,Albuquerque,NM87185,USAdNCSU—UniversityofNorthCarolinaandNorthCarolinaStateUniversity,Raleigh,NC27695-7115,USAeElectrozymeLLC,4225ExecutiveSquare,Suite400,LaJolla,CA92037,USAarticleinfoabstract
4、Articlehistory:Amicroneedle-basedself-poweredbiofuel-cellglucosesensorisdescribed.ThebiofuelcellsensormakesuseofReceived16July2014theintegrationofmodifiedcarbonpastesintohollowmicroneedledevices.Thesystemdisplaysdefineddepen-Receivedinrevisedform21July2014denceof
5、thepowerdensityvsglucoseconcentrationinartificialinterstitialfluid.AnexcellentselectivityagainstAccepted21July2014commonelectroactiveinterferencesandlong-termstabilityareobtained.Theattractiveperformanceofthede-Availableonline30July2014viceindicatesconsiderablepr
6、omiseforsubdermalglucosemonitoring.©2014ElsevierB.V.Allrightsreserved.Keywords:MicroneedlearrayGlucoseSelf-poweredsensorBiofuelcell1.Introductiongeneratepowerfromthebioelectrocatalyticreactionsofcommonmetabolites[11–13].On-bodyBFCoffersanattractiveapproachtorea
7、l-Microneedlesaremicron-sizedeviceswhichhavetheabilitytoizeanautonomousenergysupplyformedicaldevicesbyharvestingen-physicallydisrupttheouterlayeroftheskin[1].Thefieldofmicro-ergyfrombodyfluids.WhiletheprospectsforBFCsoperatinginlivingneedleshasgrownrapidlyoverthe
8、pasttwodecades[2].Advancedorganismshavebeenproposedforoveradecade[14],actualinvivomicrofabricationtechniqueshaveenabledavarietyofmicroneedledemonstrationsofon-bodyBFChavebee