足月小于胎龄儿脐血中HO-1的测定与其在脐血管上的表达

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1、中文摘要与脐血HbCO百分含量均呈正相关(P<0．05或P0．05)。结论：1sGA脐血H0一】活性显著低于AGA，无论AGA还是sGA脐血

2、HO—l活性水平与出生体重均呈正相关，说明脐血HO—l活性与胎儿富内发育及新生儿营养状况密切相关。2SGA脐血血浆HbcO的百分含量均显著低于AGA，脐向．HO一1活性水平与血浆HbC0百分含量无论AGA还是sGA均呈正相关。3H0．1在脐【l=

3、1．管上的表达SGA明显强于AGA，是由于胎儿宫内缺血缺氧，诱导HO一1基因表达，导致HO一1表达明显增高。但其酶的活性受损，加重胎盘胎儿缺m缺氧，影响胎儿生长发育。因此推测H0．cO系统不仅与妊娠高血压综合征所致小于胎龄儿的发病有关，而且与其他原因所致非匀称型小于胎龄儿的发病均关系

4、密切。关键词：血红素氧合酶(HO一1)；小于胎龄儿(sGA)；脐血；H0一C0系统；免疫组化英文摘要MeasuringHo一1inCordBloodofFuUTermSGAandItsExpressioninCordVesselsABSTRACTobjectiVe：Smallforgestationalage(SGA)，isbomnotonlywithlowbirthweight，growthretardation，high“skofasphyxiaduringdeliver)-intracranialhemorrhage，b

5、rainhypoXiainjury，barrierinmetabolismandcongenitaImalformation，10tjmestheperinatalmortalityofappropriateforgestationalage(AGA)，butalsowithpossibjlityofdelayeddeVelopmentinphysique，neuro—actionandbrainpower．Thereforeresearc

6、1ondiseasecause，prophylaxisandtrea“nentofSG

7、A，decreasingperin乱almortalityisofgIeatsignincance．Heme0xygenase(HO)isthespeed—limitenzymethatgeneratescalbonmonoxide(CO)，biIiVerdjnandFeinthecourseofhememetabolism，COisanewkindofneurotransmissionthatisinVolVedinadjustmentofmanykindsofphysiologicalfunctions：inducemen

8、tbloodvesselsrelaxationandinhibitionofplateletaggregation．BiljVerdincanreducetobilirubin．Theyarebothanti—oxidant，protectingcellagainstoxidatiVedamage．InvestigationshavealreadyshownthatHOcanincreasebIoodstreamintoutemsplacenta，acceIeratethefbrmationofbIoodvessels，and

9、protectplacentahistjocyte．Enoughbloodstreamintoutemsplacentaistheprerequisiteforhealthygrowthofaf色tus．Internalandextemalresearchesmainlvf-ocusonadultsor4英文摘要animalsbynow，whilenorelatedrepor七scanbe士、oundabouttherelationofH0一00systeminplacentatocauseofsmal】gestational

10、age．Thisdjssertatjon，bymeasuringHo—lactivityincordbloodoffhlltermhealthynewbornandSGA，percentageofHbC0inplasma，obserVingtheexpressionofH0一