血清TPS、HER-2蛋白、P53抗体、SF在乳腺癌诊断上的意义

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1、硕上学位论文血清TPS，BER一2蛋白、P53抗体、SF在乳腺癌诊断上的意义ThediagnosablevalueofserumTPS，HER一2protein，Anti．P53，SFinbreastcancerABSTRACTObjective：TheserumconcentrationofTPS，HER一2protein，Anti—P53andSFweredetectedbyenzymelinkedimmunosorbentassayinthepatientsofbreastcancerin

2、Guangxi．Tostudythevalueofcombinedassayofthefourtumourmarkersindiagnosisofbreastcancer,investigatetheirrelationshipswithclinicalandpathologicalcharacteristics．TheimmunohistochemistrymethodwasusedtodetecttheexpressionsofTPS，HER-2protein，Anti-P53andSFin

3、breastcancer,toinvestigatetherelationshipbetweenserumconcentrationandtissuesexpressionofthefourmaker．Methods：43patientswithbreastcancerwerestudied，31caseswithbenignbreastdiseasesand31caseshealthypeoplewererandomlyselectedascontrol，Theserumconcentrati

4、onofTPS，HER-2protein，Anti—P53andSFweredetectedbyenzymelinkedimmunosorbentassayinthesethreegroup．Besides，43casesofbreastcancer，31casesofbreastbenignlesiontissuesand31casesofbreastnormaltissueswereselectedinthesamepatients，theimmunohistochemistrymethod

5、wasusedtodetecttheexpressionsofTPS，HER-2protein，Anti-P53andSFinthesetissues．StatisticalanalysisWasperformedbyusingSPSS15．0Xztest、LSD-ttestandPearsoncorrelations．Results：(1)TheserumconcentrationofTPSinbreastcancergroup，benigelesiongroupandnormalcontro

6、lare25．51_-10．36ng／ml，16．784-15．09ng／ml，16．424-11．83ng／mlrespectively；theserumconcentrationofHER-2proteininthreegroupare11．244-5．68ng／ml，6．85+2．31ng／ml，6．584-2．35ng／mlrespectively；theserumconcentrationofAnti—P53inthreegroupare9．224-5．374硕上学化论文血清TPS、H

7、ER一2蛋白、P53抗体、SF在乳腺癌诊断上的意义U／L，8．55士5．71U／L，7．59士3．66U／Lrespectively；theserumconcentrationofSFinthreegroupare359．68士151．52ng／ml，156．48士133．38ng／ml，125．79-a：85．42ng／mlrespectively．TheconcentrationofTPS，HER-2protein，Anti—P53andSFinbreastcancergroupwerehi

8、gherthanthoseinnon—cancergroup，therewerestatisticalsignificanceintheconcentrationofTPS，HER一2proteinandSF(尸<0．05)．Butthereisnostatisticalsignificancebetweentheresultsofbenigeandnormalcontr01．(2)ThesensitivityratesofTPS，HER-2proteinandSFinbreastcancerw