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1、提要目的:本研究旨在观察具有疏郁清火、平肝熄风、健脾化痰作用的中药复方(眩运宁)对风火上扰、脾虚痰阻型后循环缺血性眩晕的治疗作用,并进一步探讨其作用机制,为临床应用提供可靠的依据。方法:将临床诊断为循环缺血性眩晕的患者60例随机分为两组,其中治疗组30例,给予中药眩运宁治疗,对照组30例,给予滇白珠糖浆治疗,两组均以7天为一疗程,连续治疗三个疗程。分别观察两组患者治疗前后症状变化,检测用药前后总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)和经颅多普勒超声(TCD)等各项指标的变化,并做血、尿
2、、大便常规以及肝、肾功能检查,进行统计分析,判断其疗效及用药安全性。结果:临床观察发现,眩运宁能有效改善后循环缺血性眩晕患者的症状以及TCD各项指标。治疗前后患者的血、尿、大便常规,肝、肾功能无明显变化,具有良好的疗效和安全性。结论:临床研究结果表明,以疏郁清火、平肝熄风、健脾化痰为治则拟定的眩运宁能有效地治疗风火上扰、脾虚痰阻型后循环缺血性眩晕,值得进一步深入研究和临床推广应用。关键词后循环缺血性眩晕;眩运宁;临床研究ClinicalStudyonXuanYunNingPrescriptioninTreatingWindandFireonthe
3、InterferencandSpleenphlegmtypePosteriorCirculationIschemiaVertigoSpeciality:NeurologicalmedicineofTCMAuthor:LitingChenLiliTutor:Prof.WangZhonglinAbstractObjective:ThisstudywasdesignedtoobservethepreventiveandtherapeuticeffectofposteriorcirculationischemiavertigoofXuanyunningw
4、ithShuyuQinghuo,PingganXifeng,JianpiHuatanChineseherbs,andtofurtherexploreitsmechanism,inordertoprovidereliableclinicalapplicationbasis.Methods:60casesofposteriorcirculationischemiavertigopatientswererandomlydividedintotwogroups,30casescombinedChineseherbsXuanyunningtreatment
5、group,30casesbetreatedwithdianbaizhutangjiang;bothgroupsaretreated3weeksforonecourseoftreatment.Beforeandaftertreatment,patientsofthetwogroupswererespectivelyobservedinwithsymptoms,signs,thetotalcholesterol(TC),triglyceride(TG),high-densitylipoproteincholesterol(HDL-C),low-de
6、nsitylipoproteincholesterol(LDL-C)andchangesofTCD.Checkbloodroutine,urineroutine,fecesroutineaswellasliverandkidneyfunctiontestsbeforeandafterusethemedicine,statisticalanalysistodeterminedrugefficacyandsafety.Results:TheclinicalobservationfoundthattraditionalChinesemedicine(X
7、uanyunning)caneffectivelyimprovethesymptoms,signsofposteriorcirculationischemiavertigopatientsandsignificantimprovedtheindicatorsofTCD.Therewasnosignificantdifferenceofbloodroutine,urineroutine,fecesroutineaswellasliverandkidneyfunctiontests,Thetherapyhavegoodefficacyandsafet
8、y.Conclusion:TheclinicalstudyresultsshowedthattheXuanyunningdecoctio