磁共振波谱成像联合fPSA2ftPSA、PSAD对PSA灰值区前列腺癌的诊断价值

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1、万方数据第三军医大学硕士学位论文lueofcombineduseofMRS，fPSA／tPSAandPSADindiagnosingprostatecancersatPSAgrayzoneAbstractobjective：ThepurposeofthisstudywastoexplorethevalueofcombineduseofMRS，fPSA／tPSAandPSADindiagnosingofprostatecanceratserumPSAgrayzoner4～10ng／m1)inordertoi

2、ncreasethediagnosisaccuracyofprostatecancerandavoidunnecessarybiopsy．Methods1．PatientsselectionSixtymalepatients(age>45years)whocometoourhospitaltoseeadoctorfordysuriaorPSAabnormal(4～10ng／m1)duringAugust2013toAugust2014wereretrospectiveanalyzed2．Collectio

3、nofserumsamplesandcalculationoftPSA，fPSA，prostatevolume，fPSA／tPSAandPSADSerumsampleswerecollectedforPSAdetermination．ExternalstimulatedfactorswhichmayaffectingserumlevelofPSA，suchasdigitalrectalexamination，prostateBultrasound，cystoscopy,indwellingcatheter

4、andprostaticmassage，shouldbeavoided2weeksbeforeserumcollection．BothtPSAandfPSAweredetectedbychemiluminescencemethod．fPSA／tPSAwascalculatedbyfPSAdividetPSA．BasedonMRIresults，prostatevolumewascalculatedbyequation：Prostatevolume=Anteroposteriordiameterofpros

5、tate(cm)×Right-leftdiameterofprostate(cm)×Verticaldiameterofprostate(cm)．PSADwascalculatedbytPSAdivideprostatevolume(cm3)．3．MRIandMRSexaminationThreedaysafterPSAdetermination，patient’SprostatewasscannedbyMRIandMRSusingMAGNETOMVERIO3．0TMRIequipment．Results

6、wereintroducedintoaworkstationtoanalyzethespectroscopicresultsofCholine(Cho)，Creatine(Cre)andCitrate(Cit)ofregionofinterest(ROI)，allthosethreearemetabolismproductsofprostate．2万方数据第三军医大学硕士学位论文MRSwascalculatedbasedonequation：MRS=(Cho+Cre1／Cit．TheSOcalled”RO

7、I”includedMRIsignalabnormalregionandperipheralsuspectedlesionarea．4．CollectionofpathologicalspecimensAftercompletionofPSAdetermination，MRIandMRSexamination，patientswereaskedtosignwritteninformedconsenttoundergoultrasoundguidedtransrectalprostatebiopsyortr

8、ansurethralresectiontocollectpathologicalspecimens．12一coresystematicbiopsywasused(digitalrectalexaminationwasperformedbeforesurgery,Btypeultrasoundwasusedtofindnodus，biopsycorewasincreasedinabnormalareaofMRIandMRS)．