醇质体与丁香、八角茴香挥发油的促透皮作用比较分析

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1、英文摘要StudyontheDifferenceofEnhancingEffectofEthosomesandVolatileOilofFCandFASonthePenetrationZhangYiDirectedbyprofessorMaY吼sMAbstractThecontentsofvolatileoilarehi曲inFlosCaryophylli(FC)andFructusAnisiStelIati(FAS)，2kindsoftraditionalChinsesmedicinefordispellinginternalcold．RadixAcon

2、itiBrachypodi(RAB)isaherbforexternalusingusuallyinYunnanprovincethathaveeffectsofanalgesicandanti—inflammatory．ThepermeatingdosesoftheeffectivecomponentsofRAB，totalalkaloidsthroughskinarelowwhenusedalone．Ethosomesorliposomecontainedalcoholhaseffectofincreasingthedoseofdrugpermeati

3、ingthroughskinorreservinginskin．Inthispaper,theeffectofvolatileoilofFCandFASonthepermeationoftotalalkaloidofRAB／nvitrothroughmouseskinandhairlessmouseskinwerestudiedmainly：AndethosomesofTotalalkaloidsofRABwereprepared．TransdermalpenetrationofT0talalkaloidsofRABintheethosomesthroug

4、hhairlessmouseskin加vitroWaSinvestigatedandcompared谢m7％volatileoilofFC，3％volatileoilofR～Sand3％Azone．Themaincontentsare嬲follows：1．Extractingofvolatileoilanddeterminingofthemainconstituents．VolatileoilWaSextractedbythemethodofstreamdistillation．Theconstituentswereidentifiedandtheirco

5、ntentsweremeaSuredbyGC—MS．TheresultshowedthatFChadgotten14．O％(IId馆)ofvolatileoil(containing12identifiedcompounds)when10timeswaterWaSaddedandextractedfor10hours，anditschiefconstituentWaSeugenol(83．68％)：FAShadgotten7．2％(ml／g)ofvolatileoil(containing15identifiedcompounds)when10timesw

6、aterwasaddedandextractedfor8hours，anditschiefconstituentwastrans-anethol(86．62呦．2．EnhancingeffectofvolatileoilofFCandFASonthepermeationofTotalAlkaloidsofRABthroughmouseskin／nvitro．3醇质体与挥发油对一枝蒿总碱促的透皮作用比较研究Theenhancingeffectsof1％、3％、5％、7％and10％volatileoilofFCandFASonthepermeationoft

7、otalalkaloidsofRABwereinvestigated，atestwasconductedbyallimprovedmethodofFranzdiffusioncellsand3％Azonewasusedascontr01．ThecontentofBullatineAintotalalkaloidsofRABWaSdeterminedbyHPLC．Resultshowedthatinthesameseries，7％volatileoilofFCand3％volatileoilofFASwerethebestconcentrationtoenh

8、ancepermeationthroughmouseskin．Af