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1、MCPPapersinPress.PublishedonDecember27,2017asManuscriptRA117.000121DevelopmentofMultimarkerDiagnosticModelsfromMetabolomicsAnalysisforGestationalDiabetesMellitus1231112WolinHou,XiyanMeng,AihuaZhao,WeijingZhao,JieminPan,JunlingTang,YajuanHuang,2311HuapingLi,WeiJia,FangLiu,WeipingJia1ShanghaiKeyLabor
2、atoryofDiabetes,DepartmentofEndocrinology&Metabolism,ShanghaiJiao-TongUniversityAffiliatedSixthPeople’sHospital,ShanghaiClinicalMedicalCenterofDiabetes,ShanghaiKeyClinicalCenterofMetabolicDiseases,ShanghaiInstituteforDiabetes,2Shanghai,China;DepartmentofObstetricsandGynecology,ShanghaiClinicalCente
3、rforSevereMaternalRescue,ShanghaiJiao-TongUniversityAffiliatedSixthPeople’sHospital,Shanghai,China.3CenterforTranslationalMedicine,ShanghaiJiaoTongUniversityAffiliatedSixthPeople’sHospital,Shanghai,China.CorrespondenceandrequestsformaterialsshouldbeaddressedtoF.L.(email:f-liu@sjtu.edu.cn)andW.P.J.(
4、email:wpjia@sjtu.edu.cn)Runningtitle:MultimarkerModelsofGDMfromMetabolomics1Copyright2017byTheAmericanSocietyforBiochemistryandMolecularBiology,Inc.SummaryAlthoughmetabolomicsaredesirabletounderstandthepathophysiologyofgestationaldiabetesmellitus(GDM),comprehensivemetabolomicstudiesofGDMarerare.Wea
5、imedtoofferaholisticviewofmetabolitesalterationinGDMpatientsandinvestigatethepossiblemultimarkermodelsforGDMdiagnosis.Biochemicalparametersandperinataldataof131GDMcasesand138controlswerecollected.Fastingserumsamplesat75goralglucosetolerancetestwereusedformetabolitesbyultraperformanceliquidchromatog
6、raphy-quadrupole-timeofflight-massspectrometry,ultraperformanceliquidchromatography-tripletriple-quadrupole-massspectrometryandgaschromatography-time-of-flightmassspectrometryplatforms.Significantchangeswereobservedinfreefattyacids,bileacids,branchedchainaminoacids,organicacids,lipidsandorganooxyge
7、ncompoundsbetweentwogroups.Inreceiveroperatingcharacteristic(ROC)analysis,differentcombinationsofcandidatebiomarkersandmetabolitesinmultimarkermodelsachievedsatisfactorydiscriminativeabilitiesforGDM,withthe
