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1、中国中西医结合杂志2006年8月第26卷第8期CJITWM,August2006,Vol.26,No.8#677##临床论著#中药扶正胶囊和祛邪胶囊减少Ò、Ó期大肠癌术后复发转移的队列研究11213123雒琳杨宇飞李培红吴煜张建伟吴显文高书棣刘端祺摘要目的探讨在Ò、Ó期大肠癌根治术及常规化疗放疗后应用中药扶正胶囊和祛邪胶囊减少复发转移的临床价值。方法采用前瞻性队列研究设计,选取101例大肠癌根治术及常规化疗放疗后Ò、Ó期患者,进行同期队列对照,其中治疗组53例,应用扶正胶囊及祛邪胶囊治疗,对照组48例,不加特殊干预,只定期随访,观察两组
2、1、2、3年复发转移率及复发转移时间。结果治疗组1、2、3年复发转移率分别为0、2217%、1418%,对照组为612%、2412%、3018%,两组比较2年复发转移率差异有显著性(V=51428,P<0105),1年、3年复发转移率差异无显著性(P>0105);治疗组出现复发转移的平均时间为(2612?415)个月,而对照组为(1412?412)个月,差异有显著性(P<0105)。结论扶正胶囊和祛邪胶囊在根治术后Ò、Ó期大肠癌的后续巩固治疗中可能有减少复发转移,改善生活质量的作用,值得进一步进行随机对照临床研究。关键词扶正胶囊和祛邪胶
3、囊;大肠癌;复发转移;队列研究CohortStudyonFuzhengCapsuleandQuxieCapsuleinReducingRelapseandMetastasisofCancerinPatientswithStageÒandÓColorectalCarcinomaafterOperationLUOLin,YANGYu2fei,LIPei2hong,etalDe2partmentofOncology,XiyuanHospital,ChinaAcademyofChineseMedicalSciences,Beijing(1000
4、91)AbstractObjectiveTostudytheeffectofFuzhengCapsule(FC)andQuxieCapsule(QC)inreducingrelapseandmetastasisofcolorectalcancerinstageÒandÓafterthecancerhadbeentreatedbyradicalopera2tionandsuccedentroutineradiotherapyandchemotherapy.MethodsAprospectivecohortcontrolledstudywa
5、sconductedin101patientswithcolorectalcancerinstageÒandÓafterradicaloperationandroutineradiothera2pyandchemotherapy,amongwhom53patientsweretreatedwithFCandQCand48weregivennotreatment,theywerefollowedupregularly.Therateandtimeofrelapseandmetastasiswereobservedafter1,2and3y
6、ears.ResultsOne2year,22yearand32yearrelapse2metastasisratewas0,217%and1418%respectivelyinthetreatedgroup,and612%,2412%and3018%inthecontrolgroup.Significantdifferencewasfoundonlyinthe222yearratebetweenthetwogroups(V=51428,P<0105).Averagetimeofrelapseandmetastasiswas2612?4
7、15monthsinthetreatedgroupand1412?412monthsinthecontrolgroup,showingsignificantdifferencebe2tweenthetwogroups(P<0105).ConclusionFCandQCapplyinginthesuccedentconsolidatingtreatmentforstageÒandÓcolorectalcancerafterradicaloperationmightbefavourabletoreducerelapseandmetastas
8、isandimprovequalityoflife,furtherclinicalstudywithrandomizedandcontrolledmethodisworthwhiletobeconducte
