中药加化疗对大肠癌术后复发转移的影响研究

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1、中药加化疗对大肠癌术后复发转移的影响研究茅伟达蒋立新周锦仪蒋红妹(江苏省江阴市中医院普外科四病区214400)【中图分类号】R735【文献标识码】A【文章编号】1672-5085(2011)39-0070-03【摘要】目的探讨中药联合化疗治疗大肠癌术后复发转移的临床疗效。方法将2003年6月〜2008年6月我科收治的134例大肠癌术后患者随机分为单纯化疗组(67例)和中药联合化疗组(67例)。观察患者化疗期间的不良反应及术后1、2、3年复发转移率，同时采用Karnofsky评分标准评估患者化疗前后的生活质量。结果两组患者术后1,3年复发

2、转移率无显著性差异(P>0.05),而术后2年，联合化疗组的复发转移率显著低于单纯化疗组，差异有统计学意义(P<0.05)。治疗前后比较，两组Karnofsky评分均显著提高，差异有统计学意义(P<0.05);治疗后比较，联合化疗组Karnofsky评分明显高于单纯化疗组，差异有统计学意义(P<0.05)。两组的胃肠道反应比较，差异有统计学意义(P<0.05),其他不良反应无显著性差异(P>；0.05)o结论中医药联合化疗治疗大肠癌术后患者,可减轻化疗毒副反应，降低肿瘤的复发转移，改善患者生活质量。【关

3、键词】中医疗法化疗大肠癌术后健脾消癌饮ThecliniceffectofchemotherapycombinedwithChinesemedicineinpreventingrecurrenceandmetastasisofpostoperativecolorectalcancer【Abstract】Objective：ToexploreclinicaleffectofchemotherapycombinedwithChinesemedicineinpreventingrecurrenceandmetastasisofpostopera

4、tivecolorectalcancer.Methods：134casesofpostoperativecolorectalcancerpatientswhoreceivedtreatmentinourhospitalfrom2003.6〜2008.6wererandomlydividedintotwogroups,including67casesofchemotherapygroup,67casesofcombinedgroup.The1-year,2-year,3-yearrecurrenceandmetastasisrateaft

5、eroperationandthemaintoxicitiesinchemotherapyperiodwereobserved,andthequalityoflifewasassessedbyKarnofskyscoresbeforeandaftertreatment.Result：1-year,3-yearrecurrenceandmetastasisrateafteroperationwerenotsignificantlydifferent(P>0.05),whilethedifferencewassignificantat

6、2-yearafteroperation(P<0.05).Afterchemotherapytreatment,thescoreofKarnofskywassignificantlyhigherthanthosebeforetreatment,andthescoreofKarnofskyincombinedgroupwereincreasedmoreremarkedlythanthoseinchemotherapygroup(P<0.05).Themaintoxicitiesofgastrointestinalsymptom

7、sincombinedgroupwassignificantlylowerthanthatinchemotherapygroup(P<0.05),whiletherewasnosignificantdifferenceonothertoxicitiesbetweenthetwogroups(P>0.05).Conclusions:ChemotherapycombinedwithChinesemedicinefortreatmentofpostoperativecolorectalcancercancontributetore

8、ducethetoxicitiesofchemotherapyandtherateofrecurrenceandmetastasis,andimprovethequalityoflife.【Keywords