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1、·82·药学学报ActaPharmaceuticaSinica2010,45(1):82−86MinornewconstituentsfromHeteroplexismicocephala*FANXiao-na,LINSheng,ZHUCheng-gen,YANGYong-chun,SHIJian-gong(KeyLaboratoryofBioactiveSubstancesandResourcesUtilizationofChineseHerbalMedicine,MinistryofEducationofPRC,Institute
2、ofMateriaMedica,ChineseAcademyofMedicalSciences&PekingUnionMedicalCollege,Beijing100050,China)Abstract:ByusingacombinationofvariouschromatographictechniquesincludingcolumnchromatographyoversilicagelandPharmadexLH-20andreversed-phaseHPLC,twominornewcompounds,labda-12,14-
3、dien-6β,7α,8β,17-tetraol(1),2,3-cis-6-acetyl-5-hydroxy-2-(hydroxymethylvinyl)-2,3-dihydrobenzofuran-3-olangelate(2),andaminornewnaturalproduct6-methoxy-4-methyl-3,4-dihydro-2H-naphthalen-1-one(3)havebeenisolatedfromanethanolicextractofHeteroplexismicocephala.Theirstruct
4、ureswereelucidatedwithspectroscopicdataanalysisincluding2DNMRexperiments.Keywords:Heteroplexismicocephala;minorconstituent;diterpene;benzofuranderivative;3,4-dihydro-2H-naphthalen-1-onederivativeCLCnumber:R284.1Documentcode:AArticleID:0513-4870(2010)01-0082-05小花异裂菊中的微量新
5、成分*樊晓娜,林生,朱承根,杨永春,石建功(中国医学科学院、北京协和医学院药物研究所,中草药物质基础与资源利用教育部重点实验室,北京100050)摘要:通过硅胶和PharmadexLH-20凝胶柱色谱以及反相HPLC等多种分离技术的组合应用,从小花异裂菊全草乙醇提取物中分离得到了2个微量新化合物:半日花烷-12,14-二烯-6β,7α,8β,17-四醇(1)和2,3-顺式-6-乙酰基-5-羟基-2-(羟甲基乙烯基)-2,3-二氢苯并呋喃-3-醇当归酸酯(2),以及1个微量新天然产物:6-甲氧基-4-甲基-3,4-二氢-2H-1-萘酮(
6、3)。运用包括二维核磁共振实验的波谱学数据解析确定了它们的结构。关键词:小花异裂菊;微量成分;二萜;苯并呋喃衍生物;3,4-二氢-2H-萘-1-酮衍生物anethanolicextractofthisplant.InthepreviousHeteroplexis(Compositae)isanuniquegenusdividedfromthegenusAsterL.Thisgenusconsistspaper,wereportedtheisolation,structuralelucidationofonlyfivespeciesdi
7、stributedinthelimestoneterrainsandinvitrobioassaysof11newcompoundsincludingofLongzhouandYangshuo,GuangxiProvince,twosesquiterpeneswithanunusual2,2,5,9-tetra-mainlandChina.H.micocephalaY.L.Chenisamembermethylbicyclo[6.3.0]undecanecarbonskeleton,fiveplantedandusedasafolkm
8、edicinefortreatmentofphytane-typediterpenedilactones,anent-clerodane[1]indigestionanddropsy.Aspartofaprogramto
