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1、中国临床神经科学ChinJClinNeurosci202012年第12,2020卷第(1),143~47期43论著雌激素对脑卒中后抑郁大鼠抑郁行为学及前额叶BDNF表达的影响苏巧尔1，邵蓓1，金坤林1,2，程建华1，程一帆1，林真珍1，王柳青1(温州医学院附属第一医院1脑血管科，2神经外科325000)关键词雌激素；脑卒中后抑郁；脑源性生长因子；前额叶；大鼠摘要目的：探讨雌激素对脑卒中后抑郁(PSD)大鼠的影响及分子机制。方法：应用大脑中动脉栓塞和慢性不可预见温和刺激方法制备大鼠PSD模型。将PSD大鼠分为雌激素组(PSD大鼠皮下注射雌二醇)，PSD
2、组(PSD大鼠皮下注射大豆油)和对照组(假手术，皮下注射大豆油)。3组的不同干预均持续14d。观察各组大鼠行为学和前额叶脑源性生长因子(BDNF)的含量改变。结果：雌激素组在雌二醇干预后强迫游泳测试结果表明行为学显著改善：不动时间减少，与PSD组比较(18.4±4.84vs52.1±5.38)差异有显著统计学意义(P<0.01)；雌激素组挣扎时间增加，与PSD组比较(63.8±12.31vs36.3±5.22)差异有统计学意义(P<0.05)。前额叶BDNF含量在雌激素组也显著增高：雌激素组与PSD组比较，P<0.05；PSD组与对照组比较，P<0.
3、01。结论：雌激素可能通过BDNF通路改善PSD大鼠的抑郁症状。TheEffectofEstrogenonDepressionBehaviorandBrain-derivedNeurotrophicFactoronPrefrontalCortexofPost-strokeDepressionRatsSUQiao-Er1,SHAOBei1,JINKun-Lin1,2,CHENGJian-Hua1,CHENGYi-Fan1,LINZhen-Zhen1,WANGLiu-Qing11DepartmentofCerebrovascularDisease,2De
4、partmentofNeurosurgery,theFirstAffiliatedHospitalofWenzhouMedicalCollege,Wenzhou325000,ChinaKEYWORDSestrogen;post-strokedepression;brain-derivedneurotrophicfactor;prefrontalcortex;ratABSTRACTAim:Toresearchtheeffectofestrogenonpost-strokedepression(PSD)ratsandfindoutthemechanism
5、.Methods:ThePSDanimalmodelwasbuiltbymiddlecerebralarteryocclusionandchronicmildstress.Theratsweredividedintothreegroups:estrogengroup,PSDgroupandcontrolgroup.EstrogengroupwasagroupthatPSDratswereinjectedsubcutaneouslywithestradiol,PSDgroupwasagroupthatPSDratswereinjectedsubcuta
6、neouslywithsoybeanoilandthecontrolgroupwasagroupthatsham-operatedratswereinjectedsubcutaneouslywithsoybeanoil.Thetreatmentprocesscontinuedfor14days.Thebehaviorofanimalsandexpressionofbrain-derivedneurotrophicfactor(BDNF)onprefrontalcortexwereinvestigated.Results:BehaviorsofPSDr
7、atsinforcedswimmingtestwentbetteraftertheestrogentreatment:immobilitytimesignificantlyreducedinestrogengroupaftertheestrogentreatmentcomparedwithPSDgroup[(18.4±4.84）vs(52.1±5.38)]andthedifferencebetweenestrogengroupandPSDgroupwassignificant(P<0.01).Struggletimeofestrogengroupin
8、creasedsignificantlyaftertheestrogentreatmentandtherew
