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1、32JournalofChinesePharmaceuticalSciences2004,13(1)InfluenceofpHEnvironmentonNasalAbsorptionofMeptazinolHydrochloride3SHIZhen2qiandJIANGXin2guo(DepartmentofPharmaceutics,SchoolofPharmacy,FudanUniversity,Shanghai200032,China)Abstract:AimToinvestigatetherelationship
2、betweenpHenvironmentofmeptazinolhydrochloride(MEP)anditsnasalabsorption.MethodsInsitunasalperfusionwasperformedtostudytheeffectofpHenvironmentonthenasalab2sorption.Itseffectonthetransportfromnosetobrainwasfurtherresearchedbyinvivoexperiment.ResultsIninsituperfusi
3、onexperiment,thenasalabsorptionofMEPinbasicenvironmentwassignificantlyhigherthanthatinacidcondition,butthedifferencewasnotobservedininvivoexperiment.ConclusionThepHenvironmentofmeptazinolhydroclorideinformulationcannotberegardedasanimportantfactorinfluencingnasal
4、absorptionandtransportfromnosetobrain.Keywords:nasalabsorption;pHenvironment;lipophilicdrug;meptazinolhydrochlorideCLCnumber:R944.7;R965.3Documentcode:AArticleID:100321057(2004)12032205[2]217),meptazinolhydrochloride,ananalgesic.More2Introductionover,theevaluatio
5、ninthepastoftheeffectofpropertiesRecently,nasaldrugdeliverysystem(NDDS)hasofdrugsonthetransportfromnasalcavitytoCSFwasbeenpaidmoreandmoreattention.Furthermore,thegenerallybasedontheexperimentalskillbywhichitwascourseofefficientlydeliveringdrugsorcompoundstocen2im
6、possibletoobtainPcontinuousCSFsamplesfromthetralnervoussystem(CNS)byNDDShasbecomethesameanimal,suchasrats.Thedisadvantageliedinthehighlightofresearch.Itisknownthatabsorptionacrossindividualdifferenceofratsaswellasthedifficultyinin2biologicalmembraneisrelatedtothe
7、pHenvironmentinvestigatingthiseffectonlybasedonthecomparisonoftheformulation.Anditwasalsoreportedthatboththetrans2CSFconcentrationsatasingletimepoint.Thus,weper2portofsulphisomidine,ahydrophilicdrug,fromnasalformedinvivoexperimentusinganimprovedmethodofcavitytoce
8、rebrospinalfluid(CSF)andthenasalabsorp2cisternalpuncturetosampleCSFcontinuouslyfromthesamerattostudythiseffect.tionweredependentonthedissociationofthecompou2[1
