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1、PapersBiasinmetaanalysisdetectedbyasimple,graphicaltestMatthiasEgger,GeorgeDaveySmith,MartinSchneider,ChristophMinderAbstractanalyseshavelaterbeencontradictedbylargeDepartmentofrandomisedcontrolledtrials.4SuchdiscrepancieshaveSocialMedicine,Objective:Funnelplots(plotsofeffectestimate
2、sUniversityofbroughtdiscreditonatechniquethathasbeencontroBristol,Bristolagainstsamplesize)maybeusefultodetectbiasinversialsincetheoutset.5TheappearanceofmisleadingBS82PRmetaanalysesthatwerelatercontradictedbylargeMatthiasEgger,metaanalysisisnotsurprisingconsideringthetrials.Weexamin
3、edwhetherasimpletestofreaderinsocialexistenceofpublicationbiasandthemanyotherbiasesmedicineandasymmetryoffunnelplotspredictsdiscordanceofthatmaybeintroducedintheprocessoflocating,epidemiologyresultswhenmetaanalysesarecomparedtolargeselecting,andcombiningstudies.69GeorgeDaveytrials,an
4、dweassessedtheprevalenceofbiasinSmith,Funnelplots,plotsofthetrials'effectestimatesprofessorofclinicalpublishedmetaanalyses.againstsamplesize,maybeusefultoassessthevalidityepidemiologyDesign:Medlinesearchtoidentifypairsconsistingof410ofmetaanalyses.ThefunnelplotisbasedontheDepartmento
5、fametaanalysisandasinglelargetrial(concordancefactthatprecisioninestimatingtheunderlyingSocialandofresultswasassumedifeffectswereinthesamePreventivetreatmenteffectwillincreaseasthesamplesizeofdirectionandthemetaanalyticestimatewaswithinMedicine,componentstudiesincreases.Resultsfromsm
6、allstudUniversityofBerne,30%ofthetrial);analysisoffunnelplotsfrom37ieswillscatterwidelyatthebottomofthegraph,withCH3012Berne,metaanalysesidentifiedfromahandsearchoffourSwitzerlandthespreadnarrowingamonglargerstudies.Intheleadinggeneralmedicinejournals19936and38MartinSchneider,absence
7、ofbiastheplotwillresembleasymmetricalresearchassociatemetaanalysesfromthesecond1996issueoftheinvertedfunnel.Conversely,ifthereisbias,funnelplotsChristophMinder,CochraneDatabaseofSystematicReviews.willoftenbeskewedandasymmetrical.head,medicalstatisticsMainoutcomemeasure:Degreeoffunnel
8、plotunitThev
