《不同程度失语症患者朗读激活试验的spect脑血流显像》

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1、万方数据生堡筮医堂盘查!塑!至!!旦筮!!鲞筮!翅垡!鱼』盟!!!丛鲤：旦塑!!Q!：y!!!!：堕!：!·中枢神经系统核医学·不同程度失语症患者朗读激活试验的SPECT脑血流显像陈健昊秋莲徐浩王红陈卓铭【摘要】目的分析脑损伤后的失语症患者朗读时局部脑血流(rCBF)变化及大脑激活模式。方法采用隔日法，对7例左侧脑损伤后失语症患者进行基础和词朗激活状态”Tc“一双半胱乙酯(ECD)SPECT脑血流显像，在大脑各横断层面上选取左右对称的26个区域为ROI，对各ROI进行半定量分析，比较朗读激活前后各ROIr

2、CBF变化，计算出26个区域的rCBF变化率。结果7例患者大脑都有明显激活区域，但每例不尽相同，其中朗读功能较好的5例患者以左侧大脑激活为主，朗读功能较差的2例患者表现为双侧大脑均有激活，但以右侧大脑激活为主。结论朗读激活SPECT脑显像可作为一种监测、评价语言朗读治疗对失语症患者语言功能恢复效果的有效手段。【关键词】失语；脑；局部血流；语言试验；体层摄影术，发射型计算机，单光子；ECDMechanismstudyofrecoveryfromaphasiawith”Tcm．ECDSPECTbrainima

3、gingafteroralread-ingtestCHENJian+，形uQiu—lian，XUHao，eta1．+DepartmentofNuclearMedicine，theFimtAffilia—tedHospital，jinanUniversity，Guangzhou510630，ChinaCorrespondingauthor：XUHao，Email：txh@inu．edu．cn【Abstract】objectiveTheremaybetwomechanismsforrecoveryfromap

4、hasia——repairofdam—agedlefthemispherelanguagenetworkand(or)activationofcompensatoryareasinrighthemisphere．Itis，however，stillcontroversialonwhichmechanismplaysamoreimportantrole．Thegoalofthisstudywastocomparetheregionalcerebralbloodflow(rCBF)betweenbaselin

5、eandduringoralreadinginaphasicpa—tientswhohadshowndefiniterecoveryfromafocallesioninlefthemisphere．Italsoaimedatexploringtheroleofthetwohemispheresinrecoveryfromaphasia，thusprovidingtheoreticbasisforrehabilitationthera—PY．MethodsBaselineandoralreading”Tcm

6、—ethylcysteinatedimer(ECD)brainSPECTimagingwereperformedin7patientswithaphasiaseparatelyinone—dayinterval．Semi·quantitativeanalysisofrCBFwasconductedOil26symmetricalROIsinbilateralhemispheresonthetransverseslices．TherCBFwasesti—matedbytheratioofthecountsp

7、erpixelofeachROItotheaveragecountsperpixelofthewholeencepha-lon．ThechangeinbloodflowwasrepresentedbythedifferenceinrCBFbetweenoralreadingandbaseline．ResultsTheactivatedperfusionpatternofbrainregionwasdifferentinall7aphasicpatients．In5ofthe7patients，whoser

8、eadingcapacitywererelativelypreserved，thebrainperfusionpatternwasmainlyleftlater—alized，whiletheothertwopatientswhohadpoorperformanceinreadingshowedbilateralactivationfociwithright—sideddominance．Conclusion0ralreadi