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1、ActaOphthalmologica2012Comparingintravitrealtriamcinoloneacetonideandbevacizumabinjectionsforthetreatmentofdiabeticmacularoedema:arandomizeddouble-blindstudyDavidLeonardoCruvinelIsaac,MuriloBatistaAbud,KarizaAikoFrantz,AlanRicardoRassiandMarcosAvilaDe
2、partmentofOphthalmology,FederalUniversityofGoias,Goiania,BrazilIntroductionMacularoedemaisthemaincauseofABSTRACT.visuallossindiabeticpatients,affect-Purpose:Tocomparetheeffectofasingleintravitrealinjectionoftriamcinoloneingaround30%ofthepatientswhoace
3、tonideandbevacizumabinreducingmacularthickness,whichwasmeasuredbyhavehadthediseaseformorethanopticalcoherencetomography(OCT)inpatientswithdiabeticmacularoedema20years(Kleinetal.1984).TheEarly(DMO).TreatmentDiabeticRetinopathyStudyMethods:Thepatientsre
4、ceivedasingleintravitrealinjectionof1.25mgbev-(ETDRS)investigatedtheroleandtheacizumabinonerandomlyselectedeyeand4.0mgtriamcinoloneacetonideintheuniformizationofphotocoagulationcontralateraleye.Centralfovealthicknessmeasurement(CFT)withOCTwasforthetre
5、atmentofdiabeticmaculartakenattheinitialvisitandatthe4-week,12-weekand24-weekvisits.oedema(DMO).Inthisstudy,focalorResults:Elevenpatients(22eyes)wereenrolledandstatisticallyanalysed.CFTgridmacularphotocoagulationshowedreducedintheeyestreatedwithtriamc
6、inoloneandthosetreatedwithbevacizumabinweeks4and12(p<0.05).Atthe24-weekfollow-up,nosignificantdifferencea50%reductionintheriskofdevelop-wasnoted,relativetotheinitialvisit.Comparingthetwogroupstreatedwithdif-ingmoderatevisuallossin3years.ferentdrugs,ast
7、atisticallysignificantdifferenceinCFTinweeks4and12wasHowever,in24%ofthetreatedeyes,noted,withamoresignificantreductionintriamcinolone-treatedeyes(p<0.05).visualacuity(VA)wasmaintainedRegardingvisualacuity(VA),patientstreatedwithtriamcinolonehadimproveme
8、ntorbecameworse(EarlyTreatmentinVAat4-week(p=0.02)and12-weekfollow-up(p=0.01),whilethegroupDiabeticRetinopathyStudy1985).treatedwithbevacizumabhadVAimprovementat4-weekfollow-up(p=0.02).ManystudieshavedemonstratedAmongtheeyestreatedwithtriamcin
