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1、·94·中国医学影像学杂志2008年3月第16卷第2期ChineseJMedImaging,32008,Vol16,No.2多巴胺转运蛋白PET成像诊断帕金森病何婷婷王瑞民陈英茂张锦明姚树林田嘉禾【摘要】目的:探讨多巴胺转运蛋白(DAT)显像诊断帕金森病的价值。材料和方法:对18例正常人、31例晚期帕金11森病(PD)患者分别进行C2β2CFTPET显像,采用感兴趣区(ROI)及统计参数图(SPM)进行分析,比较正常组与PD组之间的差异。结果:ROI显示PD组尾状核及壳核各区域DAT摄取明显低于对照组,重侧基底节DAT减少较对侧明显,
2、重侧的尾状核头、体及壳核前、中、后的区域内CFT摄取值分别为轻侧的94.6%、87.0%、89.6%、91.8%、95.4%。SPM图像显示DAT减低区域主要集中在两侧尾状核、壳核区域,以壳核中后部减低为著,重侧DAT减低区域明显大于11轻侧。结论:C2β2CFTPET显像能够客观显示帕金森病DAT不对称性代谢改变的区域,有助于帕金森病的诊断和疗效评价。SPM分析为一种更全面、准确的统计方法。11关键词帕金森病;C2β2CFT;多巴胺转运蛋白;脑PET显像;统计参数图中国图书资料分类法分类号R817PETImagingofDopami
3、neTransporter(DAT)intheDiagnosisofParkinson’sDiseaseHETing2ting,WANGRui2min,CHENYing2mao,ZHANGJin2ming,YAOShu2lin,TIANJia2he(DepartmentofNuclearMedicine,ThePLAGeneralHospital,Beijing100853)【Abstract】Purpose:Themarkerofpresynapticneuron,dopaminetransporter(DAT),isasensit
4、iveindicatorofneuraldamageinParkin2son’sdisease(PD).TheaimofthisstudywastoevaluatetheabnormalityofPDthroughDATPETimaging.MaterialsandMethods:Thir211ty2onepatientswithadvancedbilateralParkinson’sdiseaseunderwentC2β2CFTPETscanning.ThePETfindingwerecomparedwiththatof18norm
5、alsubjects.Twomethodsofanalysiswereemployed:regionofinterest(ROI)analysis,andstatisticalparametricmapping(SPM).Results:ROIshowedthattheDATbindingincaudateandputameninPDgroupwassignificantlyreduced(P<0.01)comparingtothenor2malcontrols,especiallyinthestriatumofthemoreseri
6、ouslydamagedside.TheDATbindinguptakeintheheadofcaudate、bodyofcaudate、anteriorputamen、intermediateputamenandposteriorputamenoftheserious2sideweresignificantlyreducedto94.6%、87.0%、89.6%、91.8%、95.4%ofthecounterpartsoftheothersideofbrain.InSPManalysis,reducedDATbindingwasal
7、sonotedinthecaudateandpos2teriorputamen.(P<0.001corrected).TheareaofDATreductionontheserious2sidewaslargerthanthecontralateralside.Conclusions:11C2β2CFTcouldrevealtheregionalchangeofDATandishelpfulindiagnosingParkinson’sdiseaseandevaluatingtherapeuticeffect.SPManalysisi
8、samoreobjectiveandaccuratemethod.11KeywordsParkinson’sdisease;C2β2CFT;dopaminetransporter(DAT);brainPETimaging
