资源描述：
《脂肪细胞因子与癌---打印》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。
1、Physiol.Res.55:233-244,2006MINIREVIEWAdipocytokinesandCancer1212D.HOUSA,J.HOUSOVÁ,Z.VERNEROVÁ,M.HALUZÍK1DepartmentofPathology,ThirdFacultyofMedicineandUniversityHospitalKrálovské2Vinohrady,ThirdDepartmentofMedicine,FirstFacultyofMedicineandGeneralUniv
2、ersityHospital,CharlesUniversity,Prague,CzechRepublicReceivedAugust17,2005AcceptedOctober17,2005On-lineavailableOctober17,2005SummaryAdiposetissue-producedhormonessignificantlyaffectthemetabolismoflipidsandcarbohydratesaswellasnumerousotherprocessesin
3、humanbody.Itisgenerallyacceptedthatendocrinedysfunctionofadiposetissuemayrepresentoneofthecausallinksbetweenobesityandinsulinresistance/diabetes.Epidemiologicalstudiesunderlinedthatobesityrepresentsasignificantriskfactorforthedevelopmentofcancer,altho
4、ughtheexactmechanismofthisrelationshipremainstobedetermined.Multiplerecentstudieshaveindicatedthatsomeofadiposetissue-derivedhormonesmaysignificantlyinfluencethegrowthandproliferationoftumorousstromaandmalignantcellswithin.Herewereviewcurrentknowledge
5、aboutpossiblerelationshipofleptinandadiponectintotheetiopathogenesisofdifferentmalignanttumors.Mostofthestudiesindicatedthatwhileleptinmaypotentiatethegrowthofcancercellsinvitro,adiponectinappearstohaveanoppositeeffect.Furtherstudiesarenecessarytodeci
6、dewhetherobesity-inducedendocrinedysfunctionofadiposetissuecandirectlyinfluencecarcinogenesisindifferenttissuesandorgans.KeywordsObesity•Adipocytokine•Leptin•Adiponectin•Cancer•AdiposetissueIntroduction2005).Theabruptchangeoccuredaslateas1994whentheFr
7、iedman´sgroup(Zhangetal.1994)discoveredAdipocytokinesareagroupofadiposetissue-leptin.Afterthisdiscovery,theadiposetissuecameintoderivedhormonesthathavebeendiscoveredsinceearlythespotlightofextensiveresearchandaroundninetieswhenthefirstmemberofthefamil
8、y–leptin–20membersoftheadipocytokinefamilyhavebeenwasdescribed.Beforethatadiposetissuewasrecognizedidentifiedsofar.onlyasanenergystoragedepotandmechanicalbarrierTheadipocytokinescanbeclassifiedintothreethushavingonlyapassivefunctioninthebody.d
