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1、REPRODUCTIVEENDOCRINOLOGYLecture:JinLei,MD,PhD.ARTcenterofTongjiHospital,TongjiMedicalCollege,HUST,Wuhan,China.INDEXReviewH-P-OaxisHormonesecretionsOvarianfunctionsReproductivecycleCyclicchangesofthereproductiveorgansQuestionThemostimportantkeypointsREVIEWThefemalereproductiveorgansandfunctions:THEC
2、ONCEPTSCONCERNEDTOTHISLECTUREMenstruation:ahealthwomenhasaregular,recurring,andpredictableuterinebleedingfromthepubertytomenopause,ifpregnancydoesnothappen.Itdependsonthenormalovulationandhormonesecretion.Menarche:thefirsttimeofthemenstruationoccurring,whichisamarksofreproductivematurationforawomen(
3、aroundage13).Menopause:thelasttimeofmenstruation,itmeanstheovarianfailuretoovulationandsecretionhormones(aroundage50).Follicle,oocyte:mentionedasfollowed.Ovulation:mentionedasfollowed.Dysmenorrhea:mentionedasfollowed.H-P-OaxisThenormalreproductivelifeofawomandependsonthecyclicinteractionbetweenHypot
4、halamus,Pituitary,andOvarythroughpositiveandnegativefeedbackloops,termedH-P-Oaxis.H-P-Oaxiscontrolandstimulateovulation,facilitateimplantationofthefertilizedoocytes,andbringaboutmenstruation.H-P-OaxisHORMONESECRETIONHypothalamicGnRHsecretion:GnRH:gonadotropinreleasinghormone;Adecapeptidehormone;Arcu
5、atenucleus;acentercontroller;Manner:pulsatile,70~90minintervals;Themechanismisnotclear.neuroendocrinology.Pituitarygonadotropinsecretion:Anteriorpituitaryglandsecreteproteinhormones:FSHandLH;FSH:FollicleStimulatingHormone;LH:LuteinizingHormone;Manner:pulsatilefashionasthesameasGnRH;Bothhypothalamusa
6、ndovarycanmodulateit’ssecretion.OvariansteroidhormonesecretionPrincipleovarianhormones:estradiolandprogesterone;Thesynthesizingmechanism:twocellstheories(asfollows):thecacell,granulosacell;Feedbackmechanism;Thetargetorgansofovarianhormones:uterus,cervix,vagina,breast,etc.OVARIANFUCTIONInbrief,ovaryh
7、ave2functions:ovulationandhormonesecretion;Ovulation:getamatureoocyte,itisaessentialmaterialpreparationforhumanreproductiveprocedure.Sexhormonesecretion:supportingthenormalenvironmentforoocytematurati
