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1、JKoreanMedSci2007;22:393-9Copyright�TheKoreanAcademyISSN1011-8934ofMedicalSciencesClinicalFeaturesReflectExonSitesofEGFRMutationsinPatientswithResectedNon-Small-CellLungCancerTheaimofthecurrentstudywastodeterminetheclinicalsignificanceaccordingtoImIINa,JinKyungR
2、ho,thesubtypesofepidermalgrowthfactorreceptor(EGFR)mutationsandpresenceofYunJungChoi,CheolHyeonKim,KRASmutationsinoperablenon-small-celllungcancer(NSCLC).WesequencedJaeSooKoh*,Baek-YeolRyoo,SungHyunYang,JaeCheolLeeexons18-21oftheEGFRtyrosinekinasedomainandexamin
3、edmutationsincodons12and13ofKRASintissuesofpatientswithNSCLCwhohadundergonesurgicalDepartmentofInternalMedicine,Departmentofresection.EGFRmutationsweremorefrequentinnever-smokersthansmokersPathology*,KoreaCancerCenterHospital,Korea(33%vs.14%,respectively;p=0.009
4、)andinfemalesthaninmales(31%vs.16%,InstituteofRadiological&MedicalSciences,Seoul,Korearespectively;p=0.036).Mutationsinexon18-19and20-21werefoundin10and22patients,respectively.Never-smokersandbroncho-alveolarcellcarcinomafea-Received:28August2006tureswerepositiv
5、elyassociatedwithamutationinexon18-19(p=0.027and0.016,Accepted:30October2006respectively).Thefive-yearsurvivalrateinpatientswithamutationinexons18-19(100%)washigherthanthatinpatientswithoutsuchmutation(47%;p=0.021).KRASAddressforcorrespondencemutationswerefoundi
6、n16patients(12%)andwerenotrelatedtotheoverallsur-JaeCheolLee,M.D.vival(p=0.742).PatientswithanEGFRmutationinexons18-19hadbettersurvivalDepartmentofInternalMedicine,KoreaCancerCenterHospital,KoreaInstituteofRadiological&Medicalthanpatientswithoutsuchmutation.Subt
7、ypesofEGFRmutationsmaybeprognos-Sciences,215-4Gongneung-dong,Nowon-gu,Seoulticfactorsinpatientsundergoingcurativeresection.139-706,KoreaTel:+82.2-970-1206,Fax:+82.2-970-2410KeyWords:Carcinoma,Non-small-cellLung;Receptor,EpidermalGrowthFactor;Genes,Ras;MutationE-
8、mail:jclee@kcch.re.krINTRODUCTIONRecentstudieshavereportedinconsistentresultsforEGFRmutationsasaprognosticfactorincancer.TheCanadianLungcanceristheleadingcauseofcance
