EGFR Mutations Year 10 Three New Drugs Emerge - Are we Closer to Cure-94935_slide_ppt.pdf

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1、EGFRMutationsYear10
ThreeNewDrugsEmerge-
AreweClosertoCure?

PresentedByThomasLynchat2014ASCOAnnualMeetingSlide2PresentedByThomasLynchat2014ASCOAnnualMeetingSlide3PresentedByThomasLynchat2014ASCOAnnualMeetingProgression-freesurvivalinEGFRmutation

2、r/>positiveandnegativepatientsPresentedByThomasLynchat2014ASCOAnnualMeetingSelectedTrialsofTKI1stLineEGFRMutationPositiveNSCLCPresentedByThomasLynchat2014ASCOAnnualMeetingSlide6PresentedByThomasLynchat2014ASCOAnnualMeetingCanwemake1stGenTKIBetter?PresentedByThomas

3、Lynchat2014ASCOAnnualMeetingPhaseIbstudyofAfatinib&CetuximabPresentedByThomasLynchat2014ASCOAnnualMeetingTumorRegressionbyT790MMutationStatus
atRecommendedDosePresentedByThomasLynchat2014ASCOAnnualMeetingCetux/AfatanibToxicityPresentedByThomasLynchat2014ASCOAn

4、nualMeetingSlide11PresentedByThomasLynchat2014ASCOAnnualMeetingNextGenEGFRTKIs:MutantSpecificAgentsEmergePresentedByThomasLynchat2014ASCOAnnualMeetingHM61713PresentedByThomasLynchat2014ASCOAnnualMeetingHM61713PresentedByThomasLynchat2014ASCOAnnualMeetingHM61713Pre

5、sentedByThomasLynchat2014ASCOAnnualMeetingCO-1686PresentedByThomasLynchat2014ASCOAnnualMeetingCO-1686PresentedByThomasLynchat2014ASCOAnnualMeetingCO-1686PresentedByThomasLynchat2014ASCOAnnualMeetingProgression-freesurvival(K-Mestimate)PresentedByThomasLynchat2014A

6、SCOAnnualMeetingAZD9291PresentedByThomasLynchat2014ASCOAnnualMeetingAZD9291PresentedByThomasLynchat2014ASCOAnnualMeetingAZD9291PresentedByThomasLynchat2014ASCOAnnualMeetingResponserate*accordingtoT790M(centraltest)status:immediatepriorEGFR-TKI,#yesvsnoPresentedByT

7、homasLynchat2014ASCOAnnualMeetingHaveweimprovedRx?PresentedByThomasLynchat2014ASCOAnnualMeetingPreliminaryEfficacyComparisonPresentedByThomasLynchat2014ASCOAnnualMeetingToxicityComparisonPresentedByThomasLynchat2014ASCOAnnualMeetingConclusionsPresentedByThomasLync

8、hat2014ASCOAnnualMeetingConclusionsPresentedByThomasLynchat2014ASCOAnnualMeetingConclusionsPresentedByThomasLynchat2014ASCOAnnualMeetingSlide30Presented