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1、Talanta80(2010)1392–1399ContentslistsavailableatScienceDirectTalantajournalhomepage:www.elsevier.com/locate/talantaDual-sensitiveprobe1-imidazole-2-(5-benzoacridine)-ethanoneforthedeterminationofaminesinenvironmentalwaterusingHPLCwithfluorescencedetectionandonli
2、neatmosphericchemicalionization-massspectrometryidentificationJinmaoYoua,b,∗,CuihuaSongb,YanyanFub,ZhiweiSuna,c,LianXiaa,YulinLia,YouruiSuoaaNorthwestPlateauInstituteofBiology,ChineseAcademyofSciences,Xining810001,PRChinabTheKeyLaboratoryofLife-OrganicAnalysis,Q
3、ufuNormalUniversity,Qufu,Shandong273165,PRChinacGraduateUniversityoftheChineseAcademyofscience,Beijing100049,PRChinaarticleinfoabstractArticlehistory:Dual-sensitiveprobeof1-imidazole-2-(5-benzoacridine)-ethanone(IBAE)forthedeterminationoffreeReceived4June2009am
4、ineswithfluorescencedetectionandonlinehighlysensitiveatmosphericchemicalionization-massReceivedinrevisedformspectrometryidentification(APCI-MS)hasbeendeveloped.2-(Benzoacridine)-5-aceticacid(BAAA)20September2009reactswithcouplingagentN,N-carbonyldiimidazole(CDI)
5、toformahighlyactivatedamideintermediateAccepted24September20091-imidazole-2-(5-benzoacridine)-ethanone(IBAE),whichisdual-sensitiveprobe.Theamideintermedi-Availableonline30September2009ate(IBAE)reactspreferablywithaminesindimethylformamide(DMF)solventtogivethehi
6、ghyieldsofderivatives.IBAE-aminederivativesarenotonlysensitivetofluorescencebutalsotoMSionizableKeywords:efficiency.Thepercentionizationıvalueschangefrom0to57.32%inaqueousacetonitrileandfrom0toHPLCAmines62.14%inaqueousmethanol.Therelativestandarddeviationsofthepe
7、akareaswithfluorescencedetec-Fluorescencetionforeachamineare<1.24%(40ng/ml,n=6).Thefluorescencedetectionlimits(atasignal-to-noiseMassspectrometryratioof3)areintherangeof0.15–0.50ng/ml.TheonlineAPCI-MSdetectionlimitsareintherangeof2-(Benzoacridine)-5-aceticacid(BA
8、AA)2.07–8.51ng/ml(atasignal-to-noiseratioof3).Therefore,thefacileIBAEintermediatederivatization1-Imidazole-2-(5-benzoacridine)-ethanoneallowedthedevelopmentofahighlysensitiv
