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1、Kimetal.DiabetolMetabSyndr(2015)7:68DOI10.1186/s13098-015-0063-yRESEARCHOpenAccessObesitywith metabolicabnormalityisassociatedwith thepresenceof carotidatherosclerosisin Koreanmen:across-sectionalstudyHa‑NaKim,Se‑HongKim,Young‑MiEunandSang‑WookSong*Abst
2、ractBackground:Obesityisariskfactorforcardiovasculardisease,butmetabolicdisturbancescanalsoleadtothedevel‑opmentofthisdisease.Therefore,weinvestigatedtheassociationsbetweenobesitysubtype,consideringbothbodyweightandmetabolicdisturbances,andcarotidathero
3、sclerosisasapredictorofcardiovasculardiseaseinKoreanmen.Methods:Datafromatotalof980menwereanalysedinthisstudy.Obesitysubtypeswereclassifiedasnormalweightwithoutmetabolicsyndrome(metabolicallyhealthynormalweight;MHNW),obesitywithoutmetabolicsyndrome(meta
4、bolicallyhealthy,butobese;MHO),normalweightwithmetabolicsyndrome(metabolicallyabnor‑mal,butnormalweight;MANW)andobesitywithmetabolicsyndrome(metabolicallyabnormalobese;MAO).Carotidintima‑mediathickness(CIMT)andcarotidplaquewereassessedusingahigh‑resolut
5、ionB‑modeultrasoundsystem.CarotidatherosclerosiswasdefinedasameanCIMTvalue>0.9mmorthepresenceofcarotidplaque.Results:MeanCIMTintheMAOsubtypewassignificantlyhigherthanthatintheMHNWcontrolgroup(0.790±0.019vs.0.747±0.013mm;p<0.001).Thepresenceofcarotidplaq
6、uewaspositivelyassociatedwithMAOsubtype[adjustedoddsratio(aOR)1.49,95%confidenceinterval(CI)1.02–2.16;p=0.039],butnotwithMHOorMANW,comparedtotheMHNWcontrolgroup.TheMAOsubtypeshowedapositiveassociationwiththepresenceofcarotidatherosclerosis(aOR1.68,95%CI
7、1.17–2.42;p=0.006).Conclusions:OnlytheMAOsubtypeshowedahigherCIMTvalueandpositiveassociationswithcarotidplaqueandcarotidatherosclerosis,butnotwithMHOandMANWsubtypes,comparedtotheMHNWcontrol.Additionalprospec‑tivestudiesareneededtoevaluatepreclinicalcaro
8、tidatherosclerosisaccordingtothesubtypesofobesity.Keywords:Obesity,Metabolicsyndrome,Carotidatherosclerosis,Carotidplaque,Carotidintima‑mediathicknessBackgroundabnormalitiesalsocausecardiometabolicdisease[2].Obesity,whichisdefine
