资源描述：
《丘脑皮层通路神经元的伤害性反应_英文_》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。
1、NeurosciBullOctober1,2009,25(5):289-295.http://www.neurosci.cnDOI:10.1007/s12264-009-0908-1289·Minireview·NeuronalnociceptiveresponsesinthalamocorticalpathwaysFeiLUO,Jin-YanWANGKeyLaboratoryofMentalHealth,InstituteofPsychology,ChineseAcademyofSciences,Beijing100101,ChinaAbstract:Thesensati
2、onofpainiscriticalforthesurvivalofanimalsandhumans.However,thebrainmechanismsunderlyingpainperceptionremainlargelyunknown.Howdoesthebraindecodethepain-evokedactivityintoaparticularsensoryexperience?Overthepastdecade,attemptshavebeenmadetoanswerthesequestionsbyemployingelectrophysiological,
3、functionalbrainimaging,andbehavioralapproaches,andsomebasicpropertiesofpainformationhavebeenrevealed.Researchershavegraduallyrecognizedthatthereexistsadistributedneuralnetworkthatparticipatesinthetransmissionandprocessingofpaininformation.Thesestudieswillfurtherguidethedevelopmentofmoreeff
4、ectivetreatmentformanydisorderssuchaschronicpain.Keywords:sensorycoding;pain;thalamocorticalcircuit;neuralnetwork1Introductionformofeither“grandmacell”or“homunculus”,whichre-sidesinthecortexandobservesallthatgoesonbelow[3]?IfHowispainsensationformed?Itisgenerallythoughtasensorysignaliscons
5、ideredtobeconveyedintheestheticthatanynociceptivestimulationcanbeperceivedwheneverpathway,itseemsnaturalthatitshouldfinallyreachsomeitexists.Thus,itwillbesurprisingthattheperceptioncouldkindsoftheend.However,evidencesuggeststhatthecon-bemodified,deformed,orevenillusioned.Therehaveal-ceptof
6、aread-outdecodermaybenotnecessary,andthatwaysbeentwocontradictoryideasabouthowsensesaresensorysignalsmaybetransformedbetweenpopulationsofcoded.The“specificity”theorymaintainsthatdifferentsen-neuronsuntilbehavioraloutputisgenerated[3,4].Meanwhile,soryfunctionsaremediatedbyactivationsofdisti
7、nctlydif-aformofvividperceptiondoesexistinourpsychologicalferentneuronswithhighlyspecificstimulussensitivities[1].experience.Therefore,whatistheneuralmechanismunder-The“pattern”theoryclaimsthatdifferentfunctionsarerep-lyingthiscognitiveperceptionoftheenvironme
