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1、AnnalsofOncologyAdvanceAccesspublishedApril29,2014AnnalsofOncology00:1–9,2014clinicalpracticeguidelinesdoi:10.1093/annonc/mdu050High-gradeglioma:ESMOClinicalPracticeGuidelines†fordiagnosis,treatmentandfollow-upR.Stupp1,M.Brada2,M.J.vandenBent3,J.-C.Tonn4&G.Pentheroudakis
2、5onbehalfoftheESMOGuidelinesWorkingGroup*12DepartmentofOncologyandCancerCentre,UniversityHospitalZurich,Zurich,Switzerland;DepartmentofMolecularandClinicalCancerMedicine,Universityof34Liverpool,ClatterbridgeCancerCentre,Wirral,UK;DepartmentofNeuro-Oncology,ErasmusMCCance
3、rCenter,Rotterdam,Netherlands;DepartmentofNeurosurgery,5Ludwig-Maximilians-University,Munich,Germany;DepartmentofMedicalOncology,MedicalSchool,UniversityofIoannina,Ioannina,GreeceDownloadedfromincidenceandepidemiologyadditionaltoolsfordiagnosisandtreatmentguidance(seebel
4、ow),andareofincreasingimportanceindailypractice.Theyearlyincidenceofmalignantgliomais∼3–5/100000withAdequatetissuecollectionandpreservation(e.g.sufficientmater-aslightpredominanceinmales.Malignantgliomamaydevelopial,freshfrozentumourtissue)shouldbeplannedprospectivelyatal
5、lages,withthepeakincidencebeinginthefifthandsixth(seeTable1).decadesoflife[1–3].Exposuretoionisingirradiationhasbeenhttp://annonc.oxfordjournals.org/associatedwithincreasedriskofdevelopmentofglioma,whileassociationwiththeuseofcellphonescouldnotbeconfirmedmolecularmarkersin
6、epidemiologicalstudies.RarehereditarysyndromescarryanGeneticlossonchromosomes1p/19q(co-deletionorlossofincreasedriskforglioma:Cowden-,Turcot-,Lynch-,Li-heterozygosity[LOH]1p/19q)isaconsequenceofachromo-Fraumenisyndromeandneurofibromatosistype1.somaltranslocationanddescrib
7、esadistincttumourentitycharacterisedbyaprolongednaturalhistoryirrespectiveoftreat-diagnosisandpathologyment,andincreasedsensitivitybothtoradiotherapy(RT)andguidelinestochemotherapy[7].LOH1p/19qshouldbeevaluatedtoclinicalpracticeThecommonlyusedWorldHealthOrganization(WHO)
8、clas-supportadiagnosisofoligodendroglioma.byguestonMay14,2014sificationdistinguishestumoursaccordingtoth
