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《胎膜早破时母血、羊水、脐血中细胞因子IL-6、IL-8、VCAM-1含量监测及其临床价值》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。
1、胎膜早破时母血、羊水、脐血中细胞因子IL-6、IL-8、VCAM-1含量监测及其临床价值【关键词】胎膜【摘要】目的探讨母血、羊水、脐血中三种细胞因子白细胞介素-6、8(interleukin-6、8)、血管细胞黏附分子-1(vascularcelladhesionmolecule,VCAM-1)对胎膜早破、绒毛膜羊膜炎和新生儿预后判断的临床意义。方法采用双抗体夹心酶联免疫吸附法检测58例胎膜早破及38例正常妊娠孕妇(对照组)母血、羊水、脐血中IL-6、IL-8、VCAM-1水平的动态变化，同时进行胎膜的病理检查。结果胎膜早破组母血、羊水、脐血中IL-6、IL-8、VCAM-1的含量均高于
2、对照组，母血、羊水、脐血中IL-6、IL-8、VCAM-1的含量随破膜时间的延长而增高，尤其破膜时间超过24h增高更为明显。绒毛膜羊膜炎患者母血、羊水、脐血中IL-6、IL-8、VCAM-1水平明显高于非绒毛膜羊膜炎患者，差异具有显著性（P<0.05,P<0.01），胎膜早破组产妇所生新生儿Apgar评分≤7分者，其母血、羊水、脐血中IL-6、IL-8、VCAM-1的含量显著高于Apgar≥8分的新生儿（P<0.05,P<0.01）。结论IL-6、IL-8、VCAM-1三种细胞因子联合检测可用于胎膜早破并绒毛膜羊膜炎的早期诊断，对新生儿预后判断也具有一定的临床价值。【关键词】白细胞介素-
3、6；白细胞介素-8；血管细胞黏附分子-1；胎膜早破；绒毛膜羊膜炎Maternalserum,amnioticfluid,umbilicalcordserumcytokinelevelsinpregnanciescomplicatedbyPROMLUDan,WANGZhi-xue,WANGXiao-ling,etal.DepartmentofObstetricsandGynecology,YangzhouUniversityCollegeofMedicine,Yangzhou225001,China【Abstract】ObjectiveToevaluatethematernalserum,
4、umbilicalcordplasmaandamnioticfluidcytokineslevels(IL-6,IL-8andVCAM-1)inpregnanciescomplicatedbyprematureruptureofmembranes(PROM).MethodsThelevelsofIL-6,IL-8andVCAM-1weredetectedbyenzymelinkedimmunosorbentassayinmaternalserum,amnioticfluid,umbilicalcordserumof58pregnantwomenwithPROMand38womenwith
5、normalpregnancies.Chorioamnionitiswashistopathologicallyconfirmedafterdelivery.ResultsThelevelsofIL-6,IL-8andVCAM-1weresignificantlyhigherinmaternalserum,amnioticfluid,umbilicalcordseruminpatientswithPROMgroupthanthoseofthecontrolgroup（P<0.05,P<0.01）.Thelongerthedurationfromruptureofmembrancestod
6、eliverywas,themoreseriouschorioamnionitiswas,andthehigherthelevelsofIL-6,IL-8andVCAM-1inmaternalserum,amnioticfluid,umbilicalcordserumwere.ThelevelsofIL-6,IL-8andVCAM-1weresignificantlyhigherinmaternalserum,amnioticfluid,umbilicalcordseruminpatientswithchorioamnionitisthanthoseofnon-chorioamnioni
7、tis（P<0.05,P<0.01）.ThelevelsofIL-6,IL-8andVCAM-1weresignificantlyhigherinmaternalserum,amnioticfluid,umbilicalcordseruminneonateswhoseApgarscore≤7thanthoseofneonateswhoseApgarscore≥8.ConclusionCytokinesmaybeimplicatedi
