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ID:37463776
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页数:9页
时间:2019-05-24
《卵泡刺激素黄体生成素比值与体外受精-胚胎移植结局的关系》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、卵泡刺激素/黄体生成素比值与体外受精-胚胎移植结局的关系作者:林文琴,杨海燕,陈霞,林金菊,叶碧绿单位:温州医学院附属第一医院生殖医学中心,浙江温州325000【摘要】目的:探讨体外受精-胚胎移植(invitrofertilization-embryotransfer,IVF-ET)治疗中卵泡刺激素/黄体生成素(FSH/LH)比值与IVF-ET结局的关系。方法:对基础卵泡刺激素(bFSH)在正常范围内(<12.5IU/L)148例不孕患者作前瞻性分析,超促排卵均采用促性腺激素释放激素激动剂(G
2、nRH-a)/重组促卵泡激素(rFSH)/人绒毛膜促性腺激素(hCG)黄体期长方案。根据FSH/LH比值将患者分为两组:A组FSH/LH<2(n=87),B组FSH/LH≥2(n=61)。比较两组患者一般资料、卵巢反应性、IVF-ET结局。结果:两组患者年龄、bFSH值、移植胚胎数、受精率、种植率、临床妊娠率差异均无显著性(P>0.05),但A组患者基础促黄体生成素(bLH)值、hCG注射日E2峰值、直径≥14mm卵泡数、获卵数显著性高于B组(P<0.05)。Gn用量、
3、周期取消率A组显著低于B组(P<0.05)。结论:FSH/LH≥2者卵巢反应性明显下降,FSH/LH比值是预测基础FSH尚在正常范围内卵巢反应性的一项较好指标。【关键词】促性腺激素;体外受精;胚胎移植;妊娠结局Relationshipbetweenfolliclestimulatinghormonetoluteinizinghormoneratioandtheoutcomeofinvitrofertilization-embryotransferLINWen-qin,YANGHai-ya
4、n,CHENXia,LINJin-ju,YEBi-lv.ReproductiveMedicineCenter,theFirstAffiliatedHospitalofWenzhouMedicalCollege,Wenzhou,325000Abstract:Objective:Toevaluatetherelationshipbetweenbasalfolliclestimulatinghormonetoluteinizinghormone(FSH/LH)ratioandtheoutcomeofinv
5、itrofertilization-embryotransfer(IVF-ET).Methods:148patientswithbasalFSHlevelinnomalrange(<12.5IU/L)werestudiedprospectively.AllpatientsreceivedGnRH-a/rFSH/humanchorionicgonadotrophin(hCG)protocolforIVF-ETtreatment.AccordingtothedifferentbasalFSH/LH
6、ratio,theyweredividedintotwogroups:87patientsasgroupA(FSH/LH<2),61patientsasgroupB(FSH/LH≥2).Basaldatas,ovarianresponseandtheoutcomesofIVFwerecomparedbetweentwogroups.Results:Therewerenosignificantdifferencesinage,basalFSH,fertilityrate,thenumber
7、oftransferredembryos,implatationrateandclinicalpregnancyratebetweentwogroups(P>0.05).However,thebasalLHlevel,theE2levelonthedayofHCG,thenumberoffollicles(≥14mm)andthenumberofoocytesobtainedingroupAweresignificantlyhigherthanthatingroupB,andtheamo
8、untofgonadotropin(Gn)used,poorresponserateweresignificantlylowerthanthatingroupB.Conclusion:BasalFSH/LHratio≥2reducestheovarianresponsetoGnsignificantly.TheBasalFSH/LHratiomaybeagoodpredictorofovarianresponseininfertilewomenwithnomal
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