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ID:37380698
大小:1.20 MB
页数:43页
时间:2019-05-22
《平喘合剂治疗小儿哮喘的临床研究》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、山东中医药大学硕士学位论文平喘合剂治疗小儿哮喘的临床研究姓名:马婷申请学位级别:硕士专业:中医儿科学指导教师:邢向晖2003.4.20提要¥S0122{目的:本文旨在运用中医和中西医结合理论,对小儿哮喘的病因病机和治法方药进行深入探讨,以寻求治疗本病的有效方药。导师多年临床研究认为哮喘是外因作用于内因的结果,痰瘀伏肺为其宿根,外邪引触伏痰,痰瘀胶结,阻塞气道,痰阻气逆为其病机,寒热夹杂常为其病性。立法宣肺化痰,降气平喘,佐以清热活血,据此遣药组方,制成平喘合剂,我们拟通过本研究客观评价其治疗作用并深入探讨其疗效机理。方
2、法:按随机分组原则,将观察对象分为平喘合剂治疗组100例,京制咳嗽痰喘丸和博利康尼对照组各50例,观察治疗前后的主要症状、体征及肺功能变化,比较患儿血浆中EOS、IL-2、sICAM-1、IgE水平的变化。结果:平喘合剂组临床控制率64%,总有效率96%,明显高于痰喘丸组的36%、84%和博利康尼组的18%、70%:平喘合剂可明显改善哮喘发作期患儿的肺通气功能;明显降低患儿血浆中EOS、IL一2、sICAAll、lgE水平,与二对照组有显著差异(P<0.Ol或P3、症状,缩短病程,对发作期寒热夹杂型小儿哮喘疗效显著,其作用机理与减轻气道阻塞、调节免疫反应及抑制气道炎症等多个环节有关。关键词小儿支气管哮喘;发作期;平喘合剂;临床研究CnjcaIStudy013JuvenjTreatedwithPingIeBronchjalAsthmaOhuanMixtureSpeciaIty:RespiratoryDisease.PediatricsMediciBeofTCM.Author:MaTingTutor:ProfessorXingXiang—huAbsttactObjective:Toi4、nvestigatetheetiologyandpathogenesisofbronchialasthmaandprobeintothemanagementmethodandprescriptionbyusingofthetheoryoftheTraditionalChineseMedicine(TCmandthecombinationofTCMandWesternMedieitie.Basedonyearsofclinicalexperiences,mytutorproposedthatthebronchialast5、hmaWaStheresultofexopathicfactorsactingonjnternalcauses。Thepathogenesisofitsparoxysmisairwayblockingofcombinationofphlegmandstasis,soreleasingthelung-Qianddissipatingphlegmtorelieveasthma.antivatingbloodflowandremovingbloodstasis,assistingwithcoolingheatispropos6、edasthemaintreatmentprincipleofit.Guidedbythese,wemadeupaprescriptionofmedicalherbsnamedPINGCHUANMIXTURE(MCHM)andobservingitsresultsfromclinicalstudies.Methods:200childrenwithasthmaarerandomlydividedinto3groups,treatedwithMc}蹦,TanChuanWanandBrieany].Observingthe7、cbildren’syndromeandphysicalsignaftertreatmentsofPC哪。comparingwiththetwocontrolgroups.ContractingthechangeofthepulmonaryfunctionandthelevelsofEOS,IL-2,slCkSl-1,IgEinthebloodofthethreegroups.Results:PC蹦cannotonlyalleviatesyndromeandphysicalsignofthechildreneffect8、ively,butalsoshortenthecoursethecourseofdiseaseandobviouslyimprovethepulmonaryfunctionofthechildren.PCI弧IcanreducethelevelsofgOS,IL2,slC&^l-t,IgEintheblood.restrainth
3、症状,缩短病程,对发作期寒热夹杂型小儿哮喘疗效显著,其作用机理与减轻气道阻塞、调节免疫反应及抑制气道炎症等多个环节有关。关键词小儿支气管哮喘;发作期;平喘合剂;临床研究CnjcaIStudy013JuvenjTreatedwithPingIeBronchjalAsthmaOhuanMixtureSpeciaIty:RespiratoryDisease.PediatricsMediciBeofTCM.Author:MaTingTutor:ProfessorXingXiang—huAbsttactObjective:Toi
4、nvestigatetheetiologyandpathogenesisofbronchialasthmaandprobeintothemanagementmethodandprescriptionbyusingofthetheoryoftheTraditionalChineseMedicine(TCmandthecombinationofTCMandWesternMedieitie.Basedonyearsofclinicalexperiences,mytutorproposedthatthebronchialast
5、hmaWaStheresultofexopathicfactorsactingonjnternalcauses。Thepathogenesisofitsparoxysmisairwayblockingofcombinationofphlegmandstasis,soreleasingthelung-Qianddissipatingphlegmtorelieveasthma.antivatingbloodflowandremovingbloodstasis,assistingwithcoolingheatispropos
6、edasthemaintreatmentprincipleofit.Guidedbythese,wemadeupaprescriptionofmedicalherbsnamedPINGCHUANMIXTURE(MCHM)andobservingitsresultsfromclinicalstudies.Methods:200childrenwithasthmaarerandomlydividedinto3groups,treatedwithMc}蹦,TanChuanWanandBrieany].Observingthe
7、cbildren’syndromeandphysicalsignaftertreatmentsofPC哪。comparingwiththetwocontrolgroups.ContractingthechangeofthepulmonaryfunctionandthelevelsofEOS,IL-2,slCkSl-1,IgEinthebloodofthethreegroups.Results:PC蹦cannotonlyalleviatesyndromeandphysicalsignofthechildreneffect
8、ively,butalsoshortenthecoursethecourseofdiseaseandobviouslyimprovethepulmonaryfunctionofthechildren.PCI弧IcanreducethelevelsofgOS,IL2,slC&^l-t,IgEintheblood.restrainth
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