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1、血管内皮生长因子受体-1对肝癌侵袭转移的影响作者:艾军华郑树国曾永毅张雷达董家鸿【摘要】目的通过检测血管内皮生长因子受体-1(vascularendothelialgrowthfactorreceptor-1,VEGFR-1)在肝癌组织中的表达,探讨VEGFR-1在肝癌侵袭、转移中的作用。方法共取82例肝癌组织和癌旁肝组织的石蜡标本,采用免疫组织化学方法检测VEGFR-1、上皮标志物E-钙黏蛋白和间叶标志物波形蛋白的表达情况,并分析其关系。对肝癌患者临床病理学指标和HBV感染中VEGFR-1的表达进行分析。结果癌旁肝组织中无VEGFR-1
2、表达,肝癌组织中VEGFR-1的表达率为89%(73/82)。VEGFR-1的表达在肿瘤分期、门静脉癌栓、肿瘤包膜、肿瘤直径、分化程度差异有统计学意义(χ2=22.192,15.934,16.751,20.154,6.487,P<0.05);对术后1、2年的复发率和术后2年生存率有影响(χ2=0.983,0.958,0.847,P<0.05);对术后1年的生存率无影响(χ2=0.359,P>0.05)。VEGFR-1与E-钙黏蛋白的表达呈负相关(r=0.765,P<0.01),而与波形蛋白的表达呈正相关(r=1.469,P>0.05
3、)。结论VEGFR-1可能在肝癌的侵袭、转移中发挥作用,其促肝癌侵袭转移可能与肝癌细胞发生上皮-间叶样表型转化有关。9【关键词】肝肿瘤;血管内皮细胞生长因子受体-1;侵袭转移【Abstract】ObjectiveToinvestigatetheeffectsofvascularendothelialgrowthfactorreceptor-1(VEGFR-1)intheinvasionandmetastasisofhepatocellularcarcinoma(HCC)bydetectingtheexpressionofVEGFR-1in
4、HCCtissues.MethodsParaffin-embeddedtissuewhichcontainingHCCtissuesandadjacenttissueswerepreparedfrompatients(n=82)withHCC,thenwereanalyzedbyimmunohistochemicaltechniquefortheexpressionofVEGFR-1,epithelialmarkerE-cadherinandmesenchymalmarkerVimentin.Therelationshipbetweent
5、heexpressionofVEGFR-1andpathologicalparameters,andthecorrelationbetweenVEGFR-1andE-cadherin,VEGFR-1andVimentinwereanalyzed.ResultsTheexpressionratesofVEGFR-1inHCCtissuesandadjacenttissueswere89%(73/82)and0,respectively.ThedifferenceofVEGFR-1expressioninportalveintumorthro
6、mbus,tumorcapsule,stage,sizeanddifferentiationgradeoftumorhadstatisticalsignificance(χ2=22.192,15.934,16.751,20.154,6.487,P<0.05).TheexpressionofVEGFR-1hadeffectonthe1-,2-yearrecurrencerateand2-yearsurvivalrate(χ2=0.983,0.958,0.847,P<0.05),butnoton1-yearsurvivalrate(χ2=0.
7、359,P>0.05).The9expressionofVEGFR-1wasnegativelycorrelatedwiththatofE-cadherin(r=0.765,P<0.01)butpositivelywiththatofVimentin(r=1.469,P>0.05).ConclusionsVEGFR-1mayplayanimportantroleininvasionandmetastasisofHCC.Epithelial-mesenchymaltransitionthatinducedbyVEGFR-1maycon
8、tributetotheinvasionandmetastasisofHCC.【Keywords】Liverneoplasm;Vascularendothelialgrowthfactorre