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1、LungCancer(2005)47,69—80Efficacyofgemcitabineplusplatinumchemotherapycomparedwithotherplatinumcontainingregimensinadvancednon-small-celllungcancer:ameta-analysisofsurvivaloutcomesT.LeChevaliera,∗,G.Scagliottib,R.Natalec,S.Dansond,R.Roselle,R.Stahelf,P.Thomasg,
2、R.M.Ruddd,J.Vansteenkisteh,N.Thatcheri,C.Manegoldj,J.-L.Pujolk,N.vanZandwijkl,C.Gridellim,J.P.vanMeerbeeckn,L.Crinoo,A.Brownp,P.FitzGeraldq,M.Aristidesp,J.H.SchillerraInstituteGustave-Roussy,39-53RueCamilleDesmoulins,F-94800Villejuif,FrancebUniversityofTorino
3、,ItalycCedars-SinaiMedicalCenter,LosAngeles,CA,USAdChristieHospital,Manchester,UKeInstitutCatalad’Oncologia,Barcelona,SpainfUniversitaetsspital,Zurich,SwitzerlandgHopitalSainteMarguerite,Marseille,FrancehUniversityHospital,Leuven,BelgiumiSt.Bartholomew’sHospi
4、tal,London,UKjThoraxklinik,Heidelberg,GermanykHopitalArnauddeVilleneuve,Montpellier,FrancelNetherlandsCancerInstitute,Amsterdam,TheNetherlandsmMoscatiHospital,Avellino,ItalynUniversityHospitalGhent,BelgiumoBellariaHospital,Bologna,ItalypM-TAG,London,UKqM-TAG,
5、Sydney,NSW,AustraliarUniversityofWisconsin,Madison,WI,USAReceived24May2004;receivedinrevisedform26October2004;accepted27October2004*Correspondingauthor.Tel.:+33142114322;fax:+33142115219.E-mailaddress:tle-che@igr.fr(T.LeChevalier).0169-5002/$—seefrontmatter©2
6、004PublishedbyElsevierIrelandLtd.doi:10.1016/j.lungcan.2004.10.01470T.LeChevalieretal.KEYWORDSSummaryPurpose:Gemcitabine—platinumcombinationactivityhasbeenclearlyestablishedMeta-analysis;inanumberofphaseIIstudies.Ithasalsobeencomparedagainstothercombina-Non-s
7、mall-celllungtionsinmanyphaseIIItrials.Itisgenerallybelievedthatallsuchregimenshavecancer;anequivalentimpactonsurvival.Thismeta-analysisaimstoquantifythetreatmentGemcitabine;effectofgemcitabineplusaplatinumagentinthetreatmentofadvancedNSCLCMetastasis;andcompa
8、rethecombinationtootherregimensusedglobally.ChemotherapyDesign:Datafromatotalof4556patientsfrom13randomizedtrialsinvestigat-inggemcitabineincombinationwithaplatinumagentversusanyotherplat
