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1、DRUGREPORT:atorvastatin.SUMMARY.DrugNameatorvastatinCompanyParke-Davis&Co(PfizerInc)HighestDevLaunchedStatusFDAApprovedFamilialType3Hyperlipoproteinemia(Adult),Hypercholesterolemia,Primary(HeterozygousFamilialAndNon-Familial)AndMixedDyslipidemia(FredricksonTypesIiaAndIib)(Adult,Pe
2、diatric),Hypertriglyceridemia(Adult),DiabetesMellitusType2-DisorderOfCardiovascularSystem,InPatientsWithMultipleRiskFactorsForCoronaryHeartDisease;Prophylaxis(Adult),DisorderOfCardiovascularSystem,InPatientsWithMultipleRiskFactorsForCoronaryHeartDisease;Prophylaxis(Adult),Familial
3、Hypercholesterolemia-Homozygous,Adjunct(Adult),DisorderOfCardiovascularSystem,Secondary;Prophylaxis(Adult)TherapyAreasAlzheimersdisease;Hypercholesterolemia;Hyperlipidemia;Familialhypercholesterolemia;CerebrovascularischemiaActionsHMGCoAreductaseinhibitor;Antiarteriosclerotic;Noot
4、ropicagent;CNSmodulator;Antihypercholesterolemicagent;AntihyperlipidemicagentTechnologiesOralformulation;Tabletformulation;SmallmoleculetherapeuticTargetHMGCoAreductaseUpdatedate27-DEC-2010ReasonforMinorEditorialAmendmentupdate.OVERVIEW.Atorvastatin(Lipitor;Sortis;Lipramar;Prevenc
5、or)isanoralHMG-CoAreductaseinhibitorandsyntheticlipid-loweringagent,developedandlaunchedbyPfizer.Theproductisindicatedforthetreatmentofprimaryhyperlipidemia,mixeddyslipidemiaanddysbetalipoproteinemia,topreventcardiovasculardiseaseinpatientswithmultipleriskfactors,andtoreducetheris
6、kofMI,stroke,revascularizationproceduresandanginainpatientswithoutcardiovasculardiseasebutwithmultipleriskfactors,includinginpatientswithtype2diabetes[509594],[509597]..AtorvastatinwasapprovedintheUKandGermanyinDecember1996forhypercholesterolemia[227414].USlaunchtookplaceinFebruar
7、y1997[238967],[1029355].JapaneselaunchtookplaceinMay2000[507267]..InApril2004,asupplementalfilingwasmadeintheEUtoincluderesultsoftheREVERSALtrialonthelabel[550263].TheFDAalsoapprovedalabelexpansionforthepreventionofcardiovasculardiseaseinAugust.2010THOMSONREUTERS.Formoreinformatio
8、ngotohttp://thomsonpharma.com/cop
